Impact of pre-existing cardiac morbidity on the risk for early cardiac toxicity
| . | Patients receiving PTCY . | Incidence of ECEs n (%) . | Received PTCY-based prophylaxis n (%) . | Type of cardiac complication: event: n (%) . | Risk for ECE regression analysis HR (95% CI) . | P value . | Day 30 mortality rate . |
|---|---|---|---|---|---|---|---|
| Patients without pre-existing cardiac morbidity (n = 371) | |||||||
| Patients without pre-existing cardiac morbidity (n = 371) | 229 (61.7) | 22 (5.9) | 18 (81.8) | Arrhythmia: 2 Pericardial disorders: 8 Heart failure: 9 Ischemia: 1 Other: 2 | Reference variable | - | 2 |
| Patients with pre-existing cardiac morbidity (n = 45) | |||||||
| Arrhythmia (n = 12) | 10 (83.3) | 5 (41.6) | 2 (40) | Arrhythmia: 3 Pericarditis: 1 Heart failure: 1 | 8.42 (3.30-21.46) | <.001 | 0 |
| Heart failure (n = 6) | 3 (50.0) | 2 (33.3) | 2 (100) | Arrhythmia: 2 | 5.77 (1.62-20.27) | .006 | 0 |
| Ischemia (n = 8) | 5 (62.5) | 1 (12.5) | 2 (100) | Arrhythmia: 1 | 2.24 (0.28-17.58) | .440 | 1 |
| Pericardial disorders (n = 6) | 3 (50.0) | 3 (50.0) | 1 (33.3) | Pericarditis: 1 Heart failure: 2 | 13.98 (3.37-57.88) | <.001 | 0 |
| Other† (n = 13) | 8 (61.5) | 2 (15.4) | 0 | Pericarditis: 1 Heart failure: 1 | 2.72 (0.64-11.50) | .170 | 1 |
| . | Patients receiving PTCY . | Incidence of ECEs n (%) . | Received PTCY-based prophylaxis n (%) . | Type of cardiac complication: event: n (%) . | Risk for ECE regression analysis HR (95% CI) . | P value . | Day 30 mortality rate . |
|---|---|---|---|---|---|---|---|
| Patients without pre-existing cardiac morbidity (n = 371) | |||||||
| Patients without pre-existing cardiac morbidity (n = 371) | 229 (61.7) | 22 (5.9) | 18 (81.8) | Arrhythmia: 2 Pericardial disorders: 8 Heart failure: 9 Ischemia: 1 Other: 2 | Reference variable | - | 2 |
| Patients with pre-existing cardiac morbidity (n = 45) | |||||||
| Arrhythmia (n = 12) | 10 (83.3) | 5 (41.6) | 2 (40) | Arrhythmia: 3 Pericarditis: 1 Heart failure: 1 | 8.42 (3.30-21.46) | <.001 | 0 |
| Heart failure (n = 6) | 3 (50.0) | 2 (33.3) | 2 (100) | Arrhythmia: 2 | 5.77 (1.62-20.27) | .006 | 0 |
| Ischemia (n = 8) | 5 (62.5) | 1 (12.5) | 2 (100) | Arrhythmia: 1 | 2.24 (0.28-17.58) | .440 | 1 |
| Pericardial disorders (n = 6) | 3 (50.0) | 3 (50.0) | 1 (33.3) | Pericarditis: 1 Heart failure: 2 | 13.98 (3.37-57.88) | <.001 | 0 |
| Other† (n = 13) | 8 (61.5) | 2 (15.4) | 0 | Pericarditis: 1 Heart failure: 1 | 2.72 (0.64-11.50) | .170 | 1 |
Other: degenerative aortic valve disease with severe insufficiency (n = 1), aneurysm of the ventricular septum (n = 1), arterial ductus in childhood, intervened (n = 1), atrial septal defect causing left to right shunt (n = 1), FVEF <50% with abnormalities in ECG and ECHO (n = 3), sinus bradycardia with ECHO abnormalities (n = 1), and right or left bundle branch block with impaired mobility on ECHO (n = 5).