The efficacy and safety of DOACs and warfarin in pivotal venous thromboembolism randomized controlled trials in Asians
| Study . | Type of DOACs and dose . | Recurrent VTE or VTE-related death, n/N (%) . | Major bleeding or clinically relevant bleeding, n/N (%) . | ||
|---|---|---|---|---|---|
| DOACs . | Warfarin . | DOACs . | Warfarin . | ||
| RECOVER I and II | Dabigatran 150 mg po twice daily | 7/292 (2.4) | 3/310 (1.0) | 22/292 (7.5) | 26/310 (8.4) |
| EINSTEIN-DVT | Rivaroxaban 15 mg twice daily 21 days, then 20 mg once daily | 3/229 (1.3) | 8/219 (3.7) | 19/227 (8.4) | 25/217 (11.5) |
| EINSTEIN-PE | Rivaroxaban 15 mg twice daily 21 days, then 20 mg once daily | 8/163 (4.9) | 5/156 (3.2) | 16/161 (9.9) | 17/154 (11.0) |
| AMPLIFY | Apixaban 10 mg twice daily 7 days, then 5 mg twice daily | 7/223 (3.1) | 9/223 (4.0) | 7/223 (3.1) | 15/223 (6.7) |
| Hokusai-VTE | Edoxaban 60 mg or 30 mg once daily | 27/866 (3.1) | 34/861 (3.9) | 75/866 (8.7) | 125/861 (14.5) |
| AMPLIFY-J34 | Apixaban 10 mg twice daily 7 days, then 5 mg twice daily | 0/40 (0) | 1/40 (2.5) | 3/40 (7.5) | 11/39 (28.2) |
| J-EINSTEIN DVT and PE35 | Rivaroxaban 10 mg twice daily or 15 mg twice daily for 3 weeks followed by 15 mg once daily | 1/78 (1.3) | 1/19 (5.3) | 6/77 (7.8) | 1/19 (5.3) |
| Study . | Type of DOACs and dose . | Recurrent VTE or VTE-related death, n/N (%) . | Major bleeding or clinically relevant bleeding, n/N (%) . | ||
|---|---|---|---|---|---|
| DOACs . | Warfarin . | DOACs . | Warfarin . | ||
| RECOVER I and II | Dabigatran 150 mg po twice daily | 7/292 (2.4) | 3/310 (1.0) | 22/292 (7.5) | 26/310 (8.4) |
| EINSTEIN-DVT | Rivaroxaban 15 mg twice daily 21 days, then 20 mg once daily | 3/229 (1.3) | 8/219 (3.7) | 19/227 (8.4) | 25/217 (11.5) |
| EINSTEIN-PE | Rivaroxaban 15 mg twice daily 21 days, then 20 mg once daily | 8/163 (4.9) | 5/156 (3.2) | 16/161 (9.9) | 17/154 (11.0) |
| AMPLIFY | Apixaban 10 mg twice daily 7 days, then 5 mg twice daily | 7/223 (3.1) | 9/223 (4.0) | 7/223 (3.1) | 15/223 (6.7) |
| Hokusai-VTE | Edoxaban 60 mg or 30 mg once daily | 27/866 (3.1) | 34/861 (3.9) | 75/866 (8.7) | 125/861 (14.5) |
| AMPLIFY-J34 | Apixaban 10 mg twice daily 7 days, then 5 mg twice daily | 0/40 (0) | 1/40 (2.5) | 3/40 (7.5) | 11/39 (28.2) |
| J-EINSTEIN DVT and PE35 | Rivaroxaban 10 mg twice daily or 15 mg twice daily for 3 weeks followed by 15 mg once daily | 1/78 (1.3) | 1/19 (5.3) | 6/77 (7.8) | 1/19 (5.3) |