Clinical characteristics of patients with EBV-associated LPDs
| Patient . | Age, y/sex . | History . | Presentation . | Diagnosis . | EBV PCR (copies per milliliter) . | Treatment . | Outcome . |
|---|---|---|---|---|---|---|---|
| 1 | 46/M | Chronic plantar warts | Longstanding constitutional symptoms | CAEBV | 3.8 × 105 | None | Alive, lost to follow-up |
| 2 | 19/M | Crohn on IS therapy (6-mercaptopurine) | Acute illness with clinical and laboratory features of HLH | HLH secondary to EBV infection | 1.54 × 105 | Rituximab, steroids, and etoposide | Alive |
| 3 | 21/M | Fevers, night sweats, weight loss | Acute illness with clinical and laboratory features of HLH | HLH with CAEBV | 3 × 106 | R-CHOP Etoposide and corticosteroids FMT conditioning, then HSCT | Recurrence of disease and death |
| 4 | 54/M | Subacute illness with weight loss and gastrointestinal symptoms | CAEBV, gastric involvement | 1.4 × 106 | Steroids, then gemcitabine, dexamethasone, and cisplatin | Death with PD and visceral perforation | |
| 5 | 27/M | Ulcerative colitis, on infliximab | Rapid deterioration with fevers, cytopenias, and hepatosplenomegaly | ANKL | 1.99 × 106 | Corticosteroids | Death |
| Patient . | Age, y/sex . | History . | Presentation . | Diagnosis . | EBV PCR (copies per milliliter) . | Treatment . | Outcome . |
|---|---|---|---|---|---|---|---|
| 1 | 46/M | Chronic plantar warts | Longstanding constitutional symptoms | CAEBV | 3.8 × 105 | None | Alive, lost to follow-up |
| 2 | 19/M | Crohn on IS therapy (6-mercaptopurine) | Acute illness with clinical and laboratory features of HLH | HLH secondary to EBV infection | 1.54 × 105 | Rituximab, steroids, and etoposide | Alive |
| 3 | 21/M | Fevers, night sweats, weight loss | Acute illness with clinical and laboratory features of HLH | HLH with CAEBV | 3 × 106 | R-CHOP Etoposide and corticosteroids FMT conditioning, then HSCT | Recurrence of disease and death |
| 4 | 54/M | Subacute illness with weight loss and gastrointestinal symptoms | CAEBV, gastric involvement | 1.4 × 106 | Steroids, then gemcitabine, dexamethasone, and cisplatin | Death with PD and visceral perforation | |
| 5 | 27/M | Ulcerative colitis, on infliximab | Rapid deterioration with fevers, cytopenias, and hepatosplenomegaly | ANKL | 1.99 × 106 | Corticosteroids | Death |
ANKL, aggressive NK leukemia; FMT, fludarabine, melphalan, thiotepa; HSCT, human stem cell transplant; IS, immunosuppressive; M, male; PCR, polymerase chain reaction; R-CHOP, rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone.