Survival analysis according to time-varying MRD positivity (BM and PB)
| . | TTP risk based on punctual MRD determination by nested and RQ-PCR in BM and PB samples . | |||||
|---|---|---|---|---|---|---|
| . | BM . | PB . | ||||
| TTP . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . |
| Nested PCR | 2.19 | (1.10-4.35) | .025 | 1.83 | (1.14-2.94) | .013 |
| RQ-PCR | 3.75 | (2.37-5.93) | <.001 | 2.33 | (1.46-3.70) | <.001 |
| . | TTP risk based on punctual MRD determination by nested and RQ-PCR in BM and PB samples . | |||||
|---|---|---|---|---|---|---|
| . | BM . | PB . | ||||
| TTP . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . |
| Nested PCR | 2.19 | (1.10-4.35) | .025 | 1.83 | (1.14-2.94) | .013 |
| RQ-PCR | 3.75 | (2.37-5.93) | <.001 | 2.33 | (1.46-3.70) | <.001 |
Analyses were performed with Cox proportional-hazard models on subjects with available information for both nested and RQ-PCR (166 subjects with 782 determinations for BM and 166 subjects with 761 determinations for PB).