Clinicopathological characteristics of the cohort
| Parameters . | n (%) . |
|---|---|
| Age, mean ± SD (range) | 49 ± 15 (20-82) |
| Sex | |
| F | 9 (27) |
| M | 24 (73) |
| Ethnicity | |
| Black | 1 (3) |
| Asian | 5 (15) |
| Caucasian | 2 (6) |
| Hispanic | 25 (76) |
| LDH | |
| Not elevated | 16 (49) |
| Elevated | 17 (51) |
| IPI score | |
| 0-2 | 23 (70) |
| 3-5 | 10 (30) |
| EBER | |
| Positive | 6 (18) |
| Negative | 27 (82) |
| Hans COO | |
| GCB | 17 (51) |
| Non-GCB | 16 (49) |
| Mutation status | 22 (67) |
| TP53 | 8 (24) |
| BCL2 | 3 (9) |
| BCL6 | 2 (6) |
| CD79b | 6 (18) |
| SGK1 | 1 (3) |
| MYD88.L265P | 2 (6) |
| NOTCH1 | 3 (9) |
| NOTCH2 | 3 (9) |
| EZH2 | 4 (12) |
| 9p24 chromosomal gain | 8 (24) |
| Stage | |
| I/II | 15 (45) |
| III/IV | 18 (55) |
| Response status | |
| CR | 22 (67) |
| Non-CR | 7 (21) |
| Unknown | 4 (12) |
| Treatment | |
| Chemo-immunotherapy | 29 (88) |
| Not done/LTF | 4 (12) |
| Parameters . | n (%) . |
|---|---|
| Age, mean ± SD (range) | 49 ± 15 (20-82) |
| Sex | |
| F | 9 (27) |
| M | 24 (73) |
| Ethnicity | |
| Black | 1 (3) |
| Asian | 5 (15) |
| Caucasian | 2 (6) |
| Hispanic | 25 (76) |
| LDH | |
| Not elevated | 16 (49) |
| Elevated | 17 (51) |
| IPI score | |
| 0-2 | 23 (70) |
| 3-5 | 10 (30) |
| EBER | |
| Positive | 6 (18) |
| Negative | 27 (82) |
| Hans COO | |
| GCB | 17 (51) |
| Non-GCB | 16 (49) |
| Mutation status | 22 (67) |
| TP53 | 8 (24) |
| BCL2 | 3 (9) |
| BCL6 | 2 (6) |
| CD79b | 6 (18) |
| SGK1 | 1 (3) |
| MYD88.L265P | 2 (6) |
| NOTCH1 | 3 (9) |
| NOTCH2 | 3 (9) |
| EZH2 | 4 (12) |
| 9p24 chromosomal gain | 8 (24) |
| Stage | |
| I/II | 15 (45) |
| III/IV | 18 (55) |
| Response status | |
| CR | 22 (67) |
| Non-CR | 7 (21) |
| Unknown | 4 (12) |
| Treatment | |
| Chemo-immunotherapy | 29 (88) |
| Not done/LTF | 4 (12) |
Double-hit tumors were excluded from this data set.
COO, cell of origin; CR, complete response; EBER, Epstein-Barr virus-encoded small RNAs; GCB: germinal center B cell; LDH, lactate dehydrogenase serum levels; LTF, lost to follow-up; non-GCB, non-germinal center B cell; REF, refractory to treatment.