Characteristics of patients with sickle cell disease hospitalized with and without COVID-19
| Characteristic . | Total (N = 5154) . | SCD COVID (N = 281) . | SCD, NO COVID (N = 4873) . | P value . |
|---|---|---|---|---|
| Age, mean (SD) | 28.2 (17.6) | 31.3 (18.0) | 28.0 (17.6) | .0021* |
| <18 y of age, % | 32.0% | 22.4% | 32.5% | .004* |
| Females, % | 54.2 | 51.2 | 54.3 | .3146 |
| SCD subtype Hemoglobin SS or Sβ0, % | 77.2 | 77.9 | 77.1 | .3318 |
| ≥3 hospitalization in past 3 y, % | 59.1 | 62.8 | 58.8 | .2511 |
| Prior history of comorbidities, % | ||||
| Asthma | 26.5 | 26.3 | 26.5 | .9594 |
| Hypertension | 26.2 | 35.2 | 25.7 | .0004* |
| Heart failure | 10.9 | 14.2 | 10.7 | .0620 |
| Ischemic heart disease | 5.6 | 7.8 | 5.5 | .0959 |
| Diabetes mellitus | 8.7 | 9.6 | 8.7 | .5835 |
| Acute/chronic kidney disease | 20.0 | 29.2 | 19.5 | <.0001* |
| Liver disease | 10.6 | 13.5 | 10.4 | .1008 |
| Obesity | 13.5 | 20.6 | 13.1 | .0003* |
| Chronic obstructive pulmonary disease | 4.4 | 6.4 | 4.2 | .0852 |
| Cerebral infarction, % | 9.1 | 9.3 | 9.1 | .9456 |
| Prior DVT and/or pulmonary embolism | 15.8 | 22.8 | 15.3 | .0009* |
| ICU admissions after index event | ||||
| Within 30 d of index event, % | 4.9 | 9.6 | 4.7 | <.001* |
| Within 90 d of index event, % | 5.7 | 11.0 | 5.3 | <.001* |
| Within 180 d of index event, % | 6.8 | 12.8 | 6.5 | <.001* |
| Characteristic . | Total (N = 5154) . | SCD COVID (N = 281) . | SCD, NO COVID (N = 4873) . | P value . |
|---|---|---|---|---|
| Age, mean (SD) | 28.2 (17.6) | 31.3 (18.0) | 28.0 (17.6) | .0021* |
| <18 y of age, % | 32.0% | 22.4% | 32.5% | .004* |
| Females, % | 54.2 | 51.2 | 54.3 | .3146 |
| SCD subtype Hemoglobin SS or Sβ0, % | 77.2 | 77.9 | 77.1 | .3318 |
| ≥3 hospitalization in past 3 y, % | 59.1 | 62.8 | 58.8 | .2511 |
| Prior history of comorbidities, % | ||||
| Asthma | 26.5 | 26.3 | 26.5 | .9594 |
| Hypertension | 26.2 | 35.2 | 25.7 | .0004* |
| Heart failure | 10.9 | 14.2 | 10.7 | .0620 |
| Ischemic heart disease | 5.6 | 7.8 | 5.5 | .0959 |
| Diabetes mellitus | 8.7 | 9.6 | 8.7 | .5835 |
| Acute/chronic kidney disease | 20.0 | 29.2 | 19.5 | <.0001* |
| Liver disease | 10.6 | 13.5 | 10.4 | .1008 |
| Obesity | 13.5 | 20.6 | 13.1 | .0003* |
| Chronic obstructive pulmonary disease | 4.4 | 6.4 | 4.2 | .0852 |
| Cerebral infarction, % | 9.1 | 9.3 | 9.1 | .9456 |
| Prior DVT and/or pulmonary embolism | 15.8 | 22.8 | 15.3 | .0009* |
| ICU admissions after index event | ||||
| Within 30 d of index event, % | 4.9 | 9.6 | 4.7 | <.001* |
| Within 90 d of index event, % | 5.7 | 11.0 | 5.3 | <.001* |
| Within 180 d of index event, % | 6.8 | 12.8 | 6.5 | <.001* |
ICU, intensive care unit; SD, standard deviation.
P-values <0.05 were considered statistically significant.