Factors associated with splenectomy failure-free survival in Cox proportional hazards models
| . | HR . | 95% CI . | P . |
|---|---|---|---|
| Univariate analysis | |||
| AIC at splenectomy (ES)* | 0.71 | 0.31-1.61 | .41 |
| AIC at splenectomy (cITP)* | 1.35 | 0.65-2.86 | .42 |
| Sex | 1.03 | 0.62-1.72 | .90 |
| Age at first AIC | 1.04 | 0.98-1.10 | .23 |
| Rituximab before splenectomy | 1.04 | 0.55-1.96 | .89 |
| Number of treatments before splenectomy | 0.95 | 0.79-1.15 | .62 |
| Time from first AIC to splenectomy | 1.00 | 0.92-1.10 | .96 |
| Age at splenectomy | 1.03 | 0.98-1.10 | .23 |
| IM diagnosed before splenectomy | 0.38 | 0.22-0.65 | .0004 |
| IM at any timepoint during follow-up | 0.24 | 0.14-0.41 | 1.4 × 10−7 |
| Multivariate analysis, model with IM diagnosed before splenectomy | |||
| AIC at splenectomy (ES)* | 1.22 | 0.50-2.94 | .67 |
| AIC at splenectomy (cITP)* | 1.35 | 0.64-2.86 | .43 |
| IM diagnosed before splenectomy | 0.39 | 0.21-0.72 | .003 |
| Multivariate analysis, model with IM diagnosed at any timepoint during follow-up | |||
| AIC at splenectomy (ES)* | 1.47 | 0.63-3.45 | .37 |
| AIC at splenectomy (cITP)* | 1.10 | 0.52-2.33 | .80 |
| IM at any timepoint during follow-up | 0.22 | 0.12-0.39 | 2.8 × 10−7 |
| . | HR . | 95% CI . | P . |
|---|---|---|---|
| Univariate analysis | |||
| AIC at splenectomy (ES)* | 0.71 | 0.31-1.61 | .41 |
| AIC at splenectomy (cITP)* | 1.35 | 0.65-2.86 | .42 |
| Sex | 1.03 | 0.62-1.72 | .90 |
| Age at first AIC | 1.04 | 0.98-1.10 | .23 |
| Rituximab before splenectomy | 1.04 | 0.55-1.96 | .89 |
| Number of treatments before splenectomy | 0.95 | 0.79-1.15 | .62 |
| Time from first AIC to splenectomy | 1.00 | 0.92-1.10 | .96 |
| Age at splenectomy | 1.03 | 0.98-1.10 | .23 |
| IM diagnosed before splenectomy | 0.38 | 0.22-0.65 | .0004 |
| IM at any timepoint during follow-up | 0.24 | 0.14-0.41 | 1.4 × 10−7 |
| Multivariate analysis, model with IM diagnosed before splenectomy | |||
| AIC at splenectomy (ES)* | 1.22 | 0.50-2.94 | .67 |
| AIC at splenectomy (cITP)* | 1.35 | 0.64-2.86 | .43 |
| IM diagnosed before splenectomy | 0.39 | 0.21-0.72 | .003 |
| Multivariate analysis, model with IM diagnosed at any timepoint during follow-up | |||
| AIC at splenectomy (ES)* | 1.47 | 0.63-3.45 | .37 |
| AIC at splenectomy (cITP)* | 1.10 | 0.52-2.33 | .80 |
| IM at any timepoint during follow-up | 0.22 | 0.12-0.39 | 2.8 × 10−7 |
Boldfaced numbers are statistically significant associations.
Autoimmune hemolytic anemia used as the reference group for this categorical variable.