Demographic and birth characteristics of DS-ALL cases and DS control subjects
| . | DS-ALL Discovery Study . | DS-ALL Replication Study . | ||||
|---|---|---|---|---|---|---|
| DS control subjects (n = 198), n (%) . | DS-ALL (n = 126), n (%) . | P value . | DS control subjects (n = 24), n (%) . | DS-ALL (n = 24), n (%) . | P value . | |
| Sex | ||||||
| Male | 91 (46.0) | 84 (66.7) | – | 14 (58.3) | 13 (54.2) | – |
| Female | 107 (54.0) | 42 (33.3) | .00037* | 10 (41.7) | 11 (45.8) | .771* |
| Race/ethnicity | ||||||
| Asian | 10 (5.1) | 2 (1.6) | – | 1 (4.2) | 1 (4.2) | – |
| Latino | 96 (48.5) | 86 (68.3) | – | 3 (12.5) | 2 (8.3) | – |
| Non-Latino White | 54 (27.3) | 32 (25.4) | – | 15 (62.5) | 20 (83.3) | – |
| Non-Latino Black | 10 (5.1) | 2 (1.6) | – | 5 (20.8) | 1 (4.2) | – |
| Other | 28 (14.1) | 4 (3.2) | .00037* | 0 | 0 | .287* |
| Missing | 0 | 0 | 0 | 0 | ||
| Age at DS-ALL diagnosis (y) | ||||||
| Median (range) | – | 4.0 (0-14.6) | – | – | <4.0, n = 13;≥4.0, n = 11† | – |
| Blood collection age (d) | ||||||
| Mean (SD) | 2.47 (2.03) | 2.03 (2.14) | .068 | N/A | N/A | – |
| Median (range) | 1.71 (0.17-15.25) | 1.46 (0-18.96) | – | N/A | N/A | – |
| Missing | 3 (1.5) | 9 (7.1) | – | 24 (100.0) | 24 (100.0) | – |
| Gestational age (wk) | ||||||
| Mean (SD) | 38.10 (2.33) | 38.22 (2.83) | .67‡ | N/A | N/A | – |
| Median (range) | 38.29 (26.42-44.71) | 38.43 (25.57-44.43) | – | N/A | N/A | – |
| Preterm (<37) | 41 (22.7) | 29 (24.0) | .78* | N/A | N/A | – |
| Missing | 17 (8.6) | 5 (4.0) | – | 24 (100.0) | 24 (100.0) | – |
| Birthweight (kg) | ||||||
| Mean (SD) | 3.00 (0.74) | 3.08 (0.60) | .31‡ | N/A | N/A | – |
| Median (range) | 3.02 (0.81-8.65) | 3.12 (0.94-4.58) | – | N/A | N/A | – |
| Missing | 4 (2.0) | 1 (0.8) | – | 24 (100.0) | 24 (100.0) | – |
| . | DS-ALL Discovery Study . | DS-ALL Replication Study . | ||||
|---|---|---|---|---|---|---|
| DS control subjects (n = 198), n (%) . | DS-ALL (n = 126), n (%) . | P value . | DS control subjects (n = 24), n (%) . | DS-ALL (n = 24), n (%) . | P value . | |
| Sex | ||||||
| Male | 91 (46.0) | 84 (66.7) | – | 14 (58.3) | 13 (54.2) | – |
| Female | 107 (54.0) | 42 (33.3) | .00037* | 10 (41.7) | 11 (45.8) | .771* |
| Race/ethnicity | ||||||
| Asian | 10 (5.1) | 2 (1.6) | – | 1 (4.2) | 1 (4.2) | – |
| Latino | 96 (48.5) | 86 (68.3) | – | 3 (12.5) | 2 (8.3) | – |
| Non-Latino White | 54 (27.3) | 32 (25.4) | – | 15 (62.5) | 20 (83.3) | – |
| Non-Latino Black | 10 (5.1) | 2 (1.6) | – | 5 (20.8) | 1 (4.2) | – |
| Other | 28 (14.1) | 4 (3.2) | .00037* | 0 | 0 | .287* |
| Missing | 0 | 0 | 0 | 0 | ||
| Age at DS-ALL diagnosis (y) | ||||||
| Median (range) | – | 4.0 (0-14.6) | – | – | <4.0, n = 13;≥4.0, n = 11† | – |
| Blood collection age (d) | ||||||
| Mean (SD) | 2.47 (2.03) | 2.03 (2.14) | .068 | N/A | N/A | – |
| Median (range) | 1.71 (0.17-15.25) | 1.46 (0-18.96) | – | N/A | N/A | – |
| Missing | 3 (1.5) | 9 (7.1) | – | 24 (100.0) | 24 (100.0) | – |
| Gestational age (wk) | ||||||
| Mean (SD) | 38.10 (2.33) | 38.22 (2.83) | .67‡ | N/A | N/A | – |
| Median (range) | 38.29 (26.42-44.71) | 38.43 (25.57-44.43) | – | N/A | N/A | – |
| Preterm (<37) | 41 (22.7) | 29 (24.0) | .78* | N/A | N/A | – |
| Missing | 17 (8.6) | 5 (4.0) | – | 24 (100.0) | 24 (100.0) | – |
| Birthweight (kg) | ||||||
| Mean (SD) | 3.00 (0.74) | 3.08 (0.60) | .31‡ | N/A | N/A | – |
| Median (range) | 3.02 (0.81-8.65) | 3.12 (0.94-4.58) | – | N/A | N/A | – |
| Missing | 4 (2.0) | 1 (0.8) | – | 24 (100.0) | 24 (100.0) | – |