Genes associated with the different megakaryocyte subsets found in yolk sac and FL and in adult BM
| MK Subset . | Fetal (YS and FL)* . | Adult (BM) . |
|---|---|---|
| Immature | FAM162A, SLC25A37, DDIT4, BNIP3, KRT18, P4HB, HSP90B1, GYPB, MT1X, HBA1 | — |
| Cycling | HSPE1, RANBP1, FABP5, H2AFZ, HMGN2, RPL22L1, HMGB1, HBD, FCER1A | POLA2, POLD2, PRIM1, LIG1† |
| Thrombopoiesis and coagulation | TUBA4A, TUBB1, PPBP, PTCRA, C19orf33, SH3BP5, MYL9, CCL5, ACRBP, HIST1H2AC, MYLK, GFI1B, NFE2, GP1BA | TUBB1, MYH9, VWF, GP1BA, GP5, GP6, P2RY1, P2RY12, GP9, ITGB3, ITGA2B‡ |
| HSC/niche supporting | RBP1, COL1A1, COLEC11, COL3A1, IGFBP3, ID3, PTN, ID1, ACTC1, VIM, MFAP4, ANGPTL6, SPARC, ANXA2, POSTN, CCBE1, COL6A2 | ACTN1, FLNA, FGFR3, TSPAN32, ZYX, GJA4, HDGF, CTGF, CMTM2, CMTM5, TPM1, TPM4, MYL9, MYO5C† |
| Translational initiation | SPINK2, IGLL1, C1QTNF4, JCHAIN, HLA-DRA, MPO, PLAC8, CD74, ZFP36L2, LTB | — |
| Immune | MS4A6A, CIQA, C1QC, C1QB, HMOX1, MYL7, ZFP36L1, FCGRT, CCL3, SAT1, CYBB, CTSS, MAFB, SAMHD1, RNASE6, S100A9, C3AR1 | CHIL1, CHIL3, CTSS, ANXA1, SPI1, CEBPB, CEBPD, CEBPE, IRF5, IRF8‡ |
| MK Subset . | Fetal (YS and FL)* . | Adult (BM) . |
|---|---|---|
| Immature | FAM162A, SLC25A37, DDIT4, BNIP3, KRT18, P4HB, HSP90B1, GYPB, MT1X, HBA1 | — |
| Cycling | HSPE1, RANBP1, FABP5, H2AFZ, HMGN2, RPL22L1, HMGB1, HBD, FCER1A | POLA2, POLD2, PRIM1, LIG1† |
| Thrombopoiesis and coagulation | TUBA4A, TUBB1, PPBP, PTCRA, C19orf33, SH3BP5, MYL9, CCL5, ACRBP, HIST1H2AC, MYLK, GFI1B, NFE2, GP1BA | TUBB1, MYH9, VWF, GP1BA, GP5, GP6, P2RY1, P2RY12, GP9, ITGB3, ITGA2B‡ |
| HSC/niche supporting | RBP1, COL1A1, COLEC11, COL3A1, IGFBP3, ID3, PTN, ID1, ACTC1, VIM, MFAP4, ANGPTL6, SPARC, ANXA2, POSTN, CCBE1, COL6A2 | ACTN1, FLNA, FGFR3, TSPAN32, ZYX, GJA4, HDGF, CTGF, CMTM2, CMTM5, TPM1, TPM4, MYL9, MYO5C† |
| Translational initiation | SPINK2, IGLL1, C1QTNF4, JCHAIN, HLA-DRA, MPO, PLAC8, CD74, ZFP36L2, LTB | — |
| Immune | MS4A6A, CIQA, C1QC, C1QB, HMOX1, MYL7, ZFP36L1, FCGRT, CCL3, SAT1, CYBB, CTSS, MAFB, SAMHD1, RNASE6, S100A9, C3AR1 | CHIL1, CHIL3, CTSS, ANXA1, SPI1, CEBPB, CEBPD, CEBPE, IRF5, IRF8‡ |