Coagulation parameters of mice with different genotypes in this study
| . | WT . | PROC+/+ . | F8−/− . | PROC+/+;F8−/− . | F9−/− . | PROC+/+;F9−/− . |
|---|---|---|---|---|---|---|
| aPTT (s) | 23.8 ± 3.2 | 22.9 ± 2.1 | 47.8 ± 4.5 | 44.6 ± 3.2 | 39.5 ± 6.2 | 37.7 ± 9.1 |
| PT (s) | 11.5 ± 4.2 | 10.5 ± 3.9 | 12.5 ± 6.2 | 14.8 ± 8.7 | 15.1 ± 5.9 | 13.3 ± 7.7 |
| Fib (mg/dL) | 105.6 ± 11.5 | 118.2 ± 13.1 | 99.6 ± 18.5 | 103.9 ± 12.5 | 95.4 ± 10.7 | 99.6 ± 13.2 |
| Plt (number ×108/mL) | 8.1 ± 0.9 | 9.3 ± 1.5 | 8.7 ± 0.9 | 8.1 ± 1.8 | 7.8 ± 2.4 | 8.1 ± 1.8 |
| . | WT . | PROC+/+ . | F8−/− . | PROC+/+;F8−/− . | F9−/− . | PROC+/+;F9−/− . |
|---|---|---|---|---|---|---|
| aPTT (s) | 23.8 ± 3.2 | 22.9 ± 2.1 | 47.8 ± 4.5 | 44.6 ± 3.2 | 39.5 ± 6.2 | 37.7 ± 9.1 |
| PT (s) | 11.5 ± 4.2 | 10.5 ± 3.9 | 12.5 ± 6.2 | 14.8 ± 8.7 | 15.1 ± 5.9 | 13.3 ± 7.7 |
| Fib (mg/dL) | 105.6 ± 11.5 | 118.2 ± 13.1 | 99.6 ± 18.5 | 103.9 ± 12.5 | 95.4 ± 10.7 | 99.6 ± 13.2 |
| Plt (number ×108/mL) | 8.1 ± 0.9 | 9.3 ± 1.5 | 8.7 ± 0.9 | 8.1 ± 1.8 | 7.8 ± 2.4 | 8.1 ± 1.8 |
Data are represent as mean ± SD. n = at least 6 mice/group.
Fib, fibrinogen measurement; Plt, platelet count; PT, prothrombin time.