Table 2.

List of differential plasma proteins compared with control malaria-infected

SymbolProtein nameFold change (log2) HGB drop with SMAP value HGB drop with SMAFold change (log2) HGB drop without SMAP value HGB drop without SMA
AHCY Adenosylhomocysteinase 0.35 .04 1.18 .06 
AK1 Adenylate kinase 1 −0.53 .03 −0.13 .5 
ALPL Alkaline phosphatase, liver/bone/kidney −0.60 .03 −0.30 .2 
AMBP α-1-microglobulin −0.35 .3 −0.66 .04 
ANGPTL6 Angiopoietin-like 6 −0.55 .04 0.07 .7 
ANPEP Alanyl (membrane) aminopeptidase −0.50 .05 −0.63 .04 
ATF6 Activating transcription factor 6 0.30 .2 0.52 .04 
ATRN Attractin −1.02 .01 −0.78 .04 
BPGM 2,3-bisphosphoglycerate mutase 0.22 .5 1.25 .04 
C4BPA Complement component 4 binding protein, α −2.08 .02 −1.81 .1 
C4BPB Complement component 4 binding protein, β −1.36 .03 −0.93 .2 
C8A Complement component 8, α polypeptide −0.45 .01 −0.36 .1 
C8G Complement component 8, γ polypeptide −0.51 .03 −0.54 .02 
CADM1 Cell adhesion molecule 1 −0.52 .1 −0.74 .04 
CD59 CD59 molecule, complement regulatory protein 0.42 .046 0.36 .2 
CD84 CD84 molecule −0.24 .4 −0.35 .02 
CR2 Complement component (3d/Epstein Barr virus) receptor 2 −1.23 .03 −0.71 .1 
CRISP3 Cysteine-rich secretory protein 3 −0.50 .1 −0.57 .001 
ECM1 Extracellular matrix protein 1 −0.29 .02 −0.21 .1 
ENO2 Enolase 2 (γ, neuronal) −0.80 .04 −0.29 .5 
FAT1 FAT atypical cadherin 1 −0.20 .03 0.10 .2 
FGFBP2 Fibroblast growth factor binding protein 2 0.45 .3 1.03 .03 
GCLC Glutamate-cysteine ligase, catalytic subunit −0.11 .6 0.78 .04 
HABP2 Hyaluronan binding protein 2 0.56 .03 0.19 .4 
HNRNPA2B1 Heterogeneous nuclear ribonucleoprotein A2/B1 0.38 .07 0.53 .02 
HPX Hemopexin −0.47 .07 −0.59 .01 
ICOSLG Inducible T-cell co-stimulator ligand −0.63 .002 −0.44 .004 
IGFALS Insulin-like growth factor binding protein, acid labile subunit −1.45 .01 −1.45 .07 
IGFBP1 Insulin-like growth factor binding protein 1 1.05 .2 1.70 .02 
IGFBP3 Insulin-like growth factor binding protein 3 −0.91 .06 −0.95 .01 
IGKC Immunoglobulin κ constant −1.26 .04 −1.06 .07 
IL6ST Interleukin 6 signal transducer −0.40 .3 −0.42 .01 
KLKB1 Kallikrein B, plasma (Fletcher factor) 1 −0.94 .004 −0.89 .01 
LIPG Lipase, endothelial −0.18 .2 −0.33 .02 
LMAN2 Lectin, mannose-binding 2 0.40 .001 0.16 .5 
MBL2 Mannose-binding lectin (protein C) 2, soluble −1.42 .2 −1.99 .03 
MELTF Melanotransferrin OS=Homo sapiens GN=MFI2 PE=1 SV=2 0.20 .02 0.11 .5 
MFI2 antigen p97 0.20 .02 0.11 .5 
NAMPT Nicotinamide phosphoribosyltransferase 0.57 .046 1.09 .1 
NBL1 Neuroblastoma 1, DAN family BMP antagonist −0.34 .4 −0.37 .02 
NCAM1 Neural cell adhesion molecule 1 −0.19 .6 −0.48 .03 
PLS3 Plastin 3 −0.99 .02 −0.34 .3 
PLTP Phospholipid transfer protein 0.45 .02 0.58 .03 
PON3 Paraoxonase 3 −1.01 .04 0.05 .9 
PRAP1 Proline-rich acidic protein 1 1.06 .046 0.99 .01 
PROCR Protein C receptor, endothelial −0.80 .04 −0.70 .2 
PRSS3P2 Putative trypsin-6 −0.37 .04 −0.22 .5 
PSMA1 Proteasome subunit α 1 0.43 .02 0.83 .047 
PSMA2 Proteasome subunit α 2 0.50 .02 1.05 .03 
PSMA4 Proteasome subunit α 4 0.39 .03 0.86 .03 
PSMA6 Proteasome subunit α 6 0.46 .02 0.99 .05 
PSMA7 Proteasome subunit α 7 0.34 .01 0.77 .07 
PSMB1 Proteasome subunit β 1 0.31 .1 0.74 .02 
PSMB10 Proteasome subunit β 10 0.74 .03 0.87 .03 
PSMB3 Proteasome subunit β 3 0.51 .05 1.05 .02 
PSMB4 Proteasome subunit β 4 0.42 .005 1.00 .04 
PSMB5 Proteasome subunit β 5 0.26 .4 1.06 .01 
PSMB6 Proteasome subunit β 6 0.36 .5 1.20 .04 
PZP Pregnancy-zone protein −1.67 .04 −1.65 .02 
SERPINA7 Serpin peptidase inhibitor, clade A −0.43 .03 −0.58 .02 
TGFBI Transforming growth factor, β-induced, 68kDa 0.62 .2 0.39 .02 
TNFAIP6 Tumor necrosis factor, α-induced protein 6 −0.41 .01 −0.01 1.0 
ZYX Zyxin −0.35 .2 −0.61 .04 
SymbolProtein nameFold change (log2) HGB drop with SMAP value HGB drop with SMAFold change (log2) HGB drop without SMAP value HGB drop without SMA
AHCY Adenosylhomocysteinase 0.35 .04 1.18 .06 
AK1 Adenylate kinase 1 −0.53 .03 −0.13 .5 
ALPL Alkaline phosphatase, liver/bone/kidney −0.60 .03 −0.30 .2 
AMBP α-1-microglobulin −0.35 .3 −0.66 .04 
ANGPTL6 Angiopoietin-like 6 −0.55 .04 0.07 .7 
ANPEP Alanyl (membrane) aminopeptidase −0.50 .05 −0.63 .04 
ATF6 Activating transcription factor 6 0.30 .2 0.52 .04 
ATRN Attractin −1.02 .01 −0.78 .04 
BPGM 2,3-bisphosphoglycerate mutase 0.22 .5 1.25 .04 
C4BPA Complement component 4 binding protein, α −2.08 .02 −1.81 .1 
C4BPB Complement component 4 binding protein, β −1.36 .03 −0.93 .2 
C8A Complement component 8, α polypeptide −0.45 .01 −0.36 .1 
C8G Complement component 8, γ polypeptide −0.51 .03 −0.54 .02 
CADM1 Cell adhesion molecule 1 −0.52 .1 −0.74 .04 
CD59 CD59 molecule, complement regulatory protein 0.42 .046 0.36 .2 
CD84 CD84 molecule −0.24 .4 −0.35 .02 
CR2 Complement component (3d/Epstein Barr virus) receptor 2 −1.23 .03 −0.71 .1 
CRISP3 Cysteine-rich secretory protein 3 −0.50 .1 −0.57 .001 
ECM1 Extracellular matrix protein 1 −0.29 .02 −0.21 .1 
ENO2 Enolase 2 (γ, neuronal) −0.80 .04 −0.29 .5 
FAT1 FAT atypical cadherin 1 −0.20 .03 0.10 .2 
FGFBP2 Fibroblast growth factor binding protein 2 0.45 .3 1.03 .03 
GCLC Glutamate-cysteine ligase, catalytic subunit −0.11 .6 0.78 .04 
HABP2 Hyaluronan binding protein 2 0.56 .03 0.19 .4 
HNRNPA2B1 Heterogeneous nuclear ribonucleoprotein A2/B1 0.38 .07 0.53 .02 
HPX Hemopexin −0.47 .07 −0.59 .01 
ICOSLG Inducible T-cell co-stimulator ligand −0.63 .002 −0.44 .004 
IGFALS Insulin-like growth factor binding protein, acid labile subunit −1.45 .01 −1.45 .07 
IGFBP1 Insulin-like growth factor binding protein 1 1.05 .2 1.70 .02 
IGFBP3 Insulin-like growth factor binding protein 3 −0.91 .06 −0.95 .01 
IGKC Immunoglobulin κ constant −1.26 .04 −1.06 .07 
IL6ST Interleukin 6 signal transducer −0.40 .3 −0.42 .01 
KLKB1 Kallikrein B, plasma (Fletcher factor) 1 −0.94 .004 −0.89 .01 
LIPG Lipase, endothelial −0.18 .2 −0.33 .02 
LMAN2 Lectin, mannose-binding 2 0.40 .001 0.16 .5 
MBL2 Mannose-binding lectin (protein C) 2, soluble −1.42 .2 −1.99 .03 
MELTF Melanotransferrin OS=Homo sapiens GN=MFI2 PE=1 SV=2 0.20 .02 0.11 .5 
MFI2 antigen p97 0.20 .02 0.11 .5 
NAMPT Nicotinamide phosphoribosyltransferase 0.57 .046 1.09 .1 
NBL1 Neuroblastoma 1, DAN family BMP antagonist −0.34 .4 −0.37 .02 
NCAM1 Neural cell adhesion molecule 1 −0.19 .6 −0.48 .03 
PLS3 Plastin 3 −0.99 .02 −0.34 .3 
PLTP Phospholipid transfer protein 0.45 .02 0.58 .03 
PON3 Paraoxonase 3 −1.01 .04 0.05 .9 
PRAP1 Proline-rich acidic protein 1 1.06 .046 0.99 .01 
PROCR Protein C receptor, endothelial −0.80 .04 −0.70 .2 
PRSS3P2 Putative trypsin-6 −0.37 .04 −0.22 .5 
PSMA1 Proteasome subunit α 1 0.43 .02 0.83 .047 
PSMA2 Proteasome subunit α 2 0.50 .02 1.05 .03 
PSMA4 Proteasome subunit α 4 0.39 .03 0.86 .03 
PSMA6 Proteasome subunit α 6 0.46 .02 0.99 .05 
PSMA7 Proteasome subunit α 7 0.34 .01 0.77 .07 
PSMB1 Proteasome subunit β 1 0.31 .1 0.74 .02 
PSMB10 Proteasome subunit β 10 0.74 .03 0.87 .03 
PSMB3 Proteasome subunit β 3 0.51 .05 1.05 .02 
PSMB4 Proteasome subunit β 4 0.42 .005 1.00 .04 
PSMB5 Proteasome subunit β 5 0.26 .4 1.06 .01 
PSMB6 Proteasome subunit β 6 0.36 .5 1.20 .04 
PZP Pregnancy-zone protein −1.67 .04 −1.65 .02 
SERPINA7 Serpin peptidase inhibitor, clade A −0.43 .03 −0.58 .02 
TGFBI Transforming growth factor, β-induced, 68kDa 0.62 .2 0.39 .02 
TNFAIP6 Tumor necrosis factor, α-induced protein 6 −0.41 .01 −0.01 1.0 
ZYX Zyxin −0.35 .2 −0.61 .04 

HGB, hemoglobin. P values <0.05 are bolded, and P values 0.05-0.09 are italicized.

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