Association of intrinsic UCB variables and unit dominance
| Multilevel logistic regression (univariate analysis) . | Outcome . | OR (95% CI)* . | P . | |
|---|---|---|---|---|
| Dominant unit, N (%) . | Nondominant unit, N (%) . | |||
| Infusion variable | ||||
| Order of infusion, N (%) | ||||
| The first unit given | 35 (73%) | 13 (27%) | 1.00 (base) | |
| The second unit given | 13 (27%) | 35 (73%) | 0.14 (0.06-0.34) | <.001 |
| Time between thaw and infusion (min) | ||||
| Median (range) | 8 (0-70) | 5 (0-77) | 1.00 (0.98-1.03) | .75 |
| Volume of cord blood unit (mL) | ||||
| Median (range) | 27 (19-150) | 25 (20-200) | 1.00 (0.99-1.02) | .93 |
| DMSO dose (g) | ||||
| Median (range) | 4 (2-20) | 3 (1-14) | 1.07 (0.92-1.24) | .38 |
| Cord blood unit information | ||||
| HLA matching, N (%) | ||||
| 4/6 | 31 (53%) | 27 (47%) | 1.00 (base) | |
| 5/6 | 15 (48%) | 16 (52%) | 0.82 (0.34-1.96) | .65 |
| 6/6 | 1 (20%) | 4 (80%) | 0.22 (0.02-2.07) | .18 |
| Cord blood unit blood group, N (%) | ||||
| A | 19 (53%) | 17 (47%) | 1.00 (base) | |
| B | 4 (29%) | 10 (71%) | 0.36 (0.9-1.36) | .13 |
| O | 24 (57%) | 18 (43%) | 1.19 (0.49-2.92) | .70 |
| AB | 1 (33%) | 2 (67%) | 0.45 (0.04-5.39) | .53 |
| Prefreeze characteristics | ||||
| Total nucleated cell count (107) per kg | ||||
| Median (range) | 2.43 (0.02- 5.81) | 2.13 (0.04-5.10) | 1.36 (0.82- 2.27) | .24 |
| CD34+ cell count (107) per kg | ||||
| Median (range) | 0.01 (0.003-0.06) | 0.009 (0.004-1.84) | 0.17 (0.0009-32.85) | .51 |
| Cell viability (%) | ||||
| Median (range) | 98 (0-100) | 98 (0 = 100) | 1.01 (0.98-1.04) | .62 |
| Post-thaw characteristics | ||||
| Total nucleated cell count (107) per kg | ||||
| Median (range) | 1.87 (0.74-4.60) | 1.84 (0.85-2.83) | 1.28 (0.52-3.14) | .60 |
| CD34+ cell count (107) per kg | ||||
| Median (range) | .009 (0.003-0.03) | 0.007 (0.004-0.02) | NC | .17 |
| CD34+ cell count (107) per kg | ||||
| Median (range) | 0.41 (0.24 to 0.59) | 0.39 (0.29-0.80 | 0.19 (0.0001-315.6) | .66 |
| CFU-GM (107) per kg | ||||
| Median (range) | 0.002 (0.00002-0.01) | 0.001 (0.00002-0.01) | NC | .67 |
| Cell viability (%) | ||||
| Median (range) | 93.5 (41-99) | 91 (23-100) | 1.00 (0.97-1.03) | .94 |
| Source FACT-NetCord Accreditation | ||||
| No | 11 (69%) | 5 (31%) | 1.00 (base) | |
| Yes | 33 (46%) | 39 (54%) | 0.38 (0.12-1.22) | .11 |
| Multilevel logistic regression (univariate analysis) . | Outcome . | OR (95% CI)* . | P . | |
|---|---|---|---|---|
| Dominant unit, N (%) . | Nondominant unit, N (%) . | |||
| Infusion variable | ||||
| Order of infusion, N (%) | ||||
| The first unit given | 35 (73%) | 13 (27%) | 1.00 (base) | |
| The second unit given | 13 (27%) | 35 (73%) | 0.14 (0.06-0.34) | <.001 |
| Time between thaw and infusion (min) | ||||
| Median (range) | 8 (0-70) | 5 (0-77) | 1.00 (0.98-1.03) | .75 |
| Volume of cord blood unit (mL) | ||||
| Median (range) | 27 (19-150) | 25 (20-200) | 1.00 (0.99-1.02) | .93 |
| DMSO dose (g) | ||||
| Median (range) | 4 (2-20) | 3 (1-14) | 1.07 (0.92-1.24) | .38 |
| Cord blood unit information | ||||
| HLA matching, N (%) | ||||
| 4/6 | 31 (53%) | 27 (47%) | 1.00 (base) | |
| 5/6 | 15 (48%) | 16 (52%) | 0.82 (0.34-1.96) | .65 |
| 6/6 | 1 (20%) | 4 (80%) | 0.22 (0.02-2.07) | .18 |
| Cord blood unit blood group, N (%) | ||||
| A | 19 (53%) | 17 (47%) | 1.00 (base) | |
| B | 4 (29%) | 10 (71%) | 0.36 (0.9-1.36) | .13 |
| O | 24 (57%) | 18 (43%) | 1.19 (0.49-2.92) | .70 |
| AB | 1 (33%) | 2 (67%) | 0.45 (0.04-5.39) | .53 |
| Prefreeze characteristics | ||||
| Total nucleated cell count (107) per kg | ||||
| Median (range) | 2.43 (0.02- 5.81) | 2.13 (0.04-5.10) | 1.36 (0.82- 2.27) | .24 |
| CD34+ cell count (107) per kg | ||||
| Median (range) | 0.01 (0.003-0.06) | 0.009 (0.004-1.84) | 0.17 (0.0009-32.85) | .51 |
| Cell viability (%) | ||||
| Median (range) | 98 (0-100) | 98 (0 = 100) | 1.01 (0.98-1.04) | .62 |
| Post-thaw characteristics | ||||
| Total nucleated cell count (107) per kg | ||||
| Median (range) | 1.87 (0.74-4.60) | 1.84 (0.85-2.83) | 1.28 (0.52-3.14) | .60 |
| CD34+ cell count (107) per kg | ||||
| Median (range) | .009 (0.003-0.03) | 0.007 (0.004-0.02) | NC | .17 |
| CD34+ cell count (107) per kg | ||||
| Median (range) | 0.41 (0.24 to 0.59) | 0.39 (0.29-0.80 | 0.19 (0.0001-315.6) | .66 |
| CFU-GM (107) per kg | ||||
| Median (range) | 0.002 (0.00002-0.01) | 0.001 (0.00002-0.01) | NC | .67 |
| Cell viability (%) | ||||
| Median (range) | 93.5 (41-99) | 91 (23-100) | 1.00 (0.97-1.03) | .94 |
| Source FACT-NetCord Accreditation | ||||
| No | 11 (69%) | 5 (31%) | 1.00 (base) | |
| Yes | 33 (46%) | 39 (54%) | 0.38 (0.12-1.22) | .11 |
The odds ratio (OR) represents the odds of being a winning unit in a particular group relative to the odds of being a winning unit in the reference group. OR derived from univariate multilevel logistic regression with patient as the grouping variable. Multivariate analysis not performed because of the small sample size.