Racial and ethnic differences in treatment-related outcomes and survival
Outcomes . | No. . | % . | NH White (N = 497) . | NH Black (N = 126) . | Hispanic (N = 117) . | Other (N = 82) . | P . | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
No. . | % . | No. . | % . | No. . | % . | No. . | % . | ||||
Weeks at risk (follow-up) | |||||||||||
Mean no. of weeks | 96 | 103 | 73 | 104 | 78 | ||||||
Median no. of weeks | 68 | 74 | 52 | 71 | 58 | ||||||
Treatment (N = 822) | |||||||||||
Induction | 572 | 70 | 336 | 68 | 86 | 68 | 94 | 80 | 56 | 68 | |
Nonintensive | 192 | 23 | 130 | 26 | 28 | 22 | 18 | 15 | 16 | 20 | |
Supportive care | 58 | 7 | 31 | 6 | 12 | 10 | 5 | 4 | 10 | 12 | |
For patients receiving induction therapy (N = 572) | |||||||||||
Treatment response after induction | .01 | ||||||||||
Complete response | 395 | 69 | 226 | 67 | 58 | 67 | 70 | 74 | 41 | 73 | |
Cri | 49 | 9 | 33 | 10 | 8 | 9 | 6 | 6 | 2 | 4 | |
MLFS | 7 | 1 | 2 | 1 | 0 | 0 | 5 | 5 | 0 | 0 | |
PR | 32 | 6 | 22 | 7 | 3 | 3 | 2 | 2 | 5 | 9 | |
Treatment failure | 89 | 16 | 53 | 16 | 17 | 20 | 11 | 12 | 8 | 14 | |
Relapse (among the 483 responders) | |||||||||||
No | 266 | 55 | 157 | 55 | 34 | 49 | 45 | 54 | 30 | 63 | |
Yes | 184 | 38 | 115 | 41 | 26 | 38 | 29 | 35 | 14 | 29 | |
Missing | 33 | 7 | 11 | 4 | 9 | 13 | 9 | 11 | 4 | 8 | |
For patients receiving nonintensive therapy (N = 192) | |||||||||||
Relapse (among 72 responders) | .13 | ||||||||||
No | 22 | 31 | 20 | 38 | 1 | 11 | 1 | 17 | 0 | 0 | |
Yes | 42 | 58 | 27 | 51 | 6 | 67 | 5 | 83 | 4 | 100 | |
Missing | 8 | 11 | 6 | 11 | 2 | 22 | 0 | 0 | 0 | 0 | |
All AML regardless of treatment (N = 822) | |||||||||||
Death within 90 days | |||||||||||
No/missing | 735 | 89 | 442 | 89 | 110 | 87 | 110 | 94 | 73 | 89 | |
Yes | 87 | 11 | 55 | 11 | 16 | 13 | 7 | 6 | 9 | 11 | |
One-year relapse-free survival | .17 | ||||||||||
No/missing | 412 | 50 | 240 | 48 | 72 | 57 | 54 | 46 | 46 | 56 | |
Yes | 410 | 50 | 257 | 52 | 54 | 43 | 63 | 54 | 36 | 44 | |
Two-year relapse-free survival | .17 | ||||||||||
No/missing | 589 | 72 | 352 | 71 | 96 | 76 | 77 | 66 | 64 | 78 | |
Yes | 233 | 28 | 145 | 29 | 30 | 24 | 40 | 34 | 18 | 22 | |
One-year overall survival | .13 | ||||||||||
No/missing | 228 | 28 | 138 | 28 | 43 | 34 | 24 | 21 | 23 | 28 | |
Yes | 594 | 72 | 359 | 72 | 83 | 66 | 93 | 79 | 59 | 72 | |
Two-year overall survival | .17 | ||||||||||
No/missing | 341 | 41 | 212 | 43 | 59 | 47 | 42 | 36 | 28 | 34 | |
Yes | 481 | 59 | 285 | 57 | 67 | 53 | 75 | 64 | 54 | 66 |
Outcomes . | No. . | % . | NH White (N = 497) . | NH Black (N = 126) . | Hispanic (N = 117) . | Other (N = 82) . | P . | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
No. . | % . | No. . | % . | No. . | % . | No. . | % . | ||||
Weeks at risk (follow-up) | |||||||||||
Mean no. of weeks | 96 | 103 | 73 | 104 | 78 | ||||||
Median no. of weeks | 68 | 74 | 52 | 71 | 58 | ||||||
Treatment (N = 822) | |||||||||||
Induction | 572 | 70 | 336 | 68 | 86 | 68 | 94 | 80 | 56 | 68 | |
Nonintensive | 192 | 23 | 130 | 26 | 28 | 22 | 18 | 15 | 16 | 20 | |
Supportive care | 58 | 7 | 31 | 6 | 12 | 10 | 5 | 4 | 10 | 12 | |
For patients receiving induction therapy (N = 572) | |||||||||||
Treatment response after induction | .01 | ||||||||||
Complete response | 395 | 69 | 226 | 67 | 58 | 67 | 70 | 74 | 41 | 73 | |
Cri | 49 | 9 | 33 | 10 | 8 | 9 | 6 | 6 | 2 | 4 | |
MLFS | 7 | 1 | 2 | 1 | 0 | 0 | 5 | 5 | 0 | 0 | |
PR | 32 | 6 | 22 | 7 | 3 | 3 | 2 | 2 | 5 | 9 | |
Treatment failure | 89 | 16 | 53 | 16 | 17 | 20 | 11 | 12 | 8 | 14 | |
Relapse (among the 483 responders) | |||||||||||
No | 266 | 55 | 157 | 55 | 34 | 49 | 45 | 54 | 30 | 63 | |
Yes | 184 | 38 | 115 | 41 | 26 | 38 | 29 | 35 | 14 | 29 | |
Missing | 33 | 7 | 11 | 4 | 9 | 13 | 9 | 11 | 4 | 8 | |
For patients receiving nonintensive therapy (N = 192) | |||||||||||
Relapse (among 72 responders) | .13 | ||||||||||
No | 22 | 31 | 20 | 38 | 1 | 11 | 1 | 17 | 0 | 0 | |
Yes | 42 | 58 | 27 | 51 | 6 | 67 | 5 | 83 | 4 | 100 | |
Missing | 8 | 11 | 6 | 11 | 2 | 22 | 0 | 0 | 0 | 0 | |
All AML regardless of treatment (N = 822) | |||||||||||
Death within 90 days | |||||||||||
No/missing | 735 | 89 | 442 | 89 | 110 | 87 | 110 | 94 | 73 | 89 | |
Yes | 87 | 11 | 55 | 11 | 16 | 13 | 7 | 6 | 9 | 11 | |
One-year relapse-free survival | .17 | ||||||||||
No/missing | 412 | 50 | 240 | 48 | 72 | 57 | 54 | 46 | 46 | 56 | |
Yes | 410 | 50 | 257 | 52 | 54 | 43 | 63 | 54 | 36 | 44 | |
Two-year relapse-free survival | .17 | ||||||||||
No/missing | 589 | 72 | 352 | 71 | 96 | 76 | 77 | 66 | 64 | 78 | |
Yes | 233 | 28 | 145 | 29 | 30 | 24 | 40 | 34 | 18 | 22 | |
One-year overall survival | .13 | ||||||||||
No/missing | 228 | 28 | 138 | 28 | 43 | 34 | 24 | 21 | 23 | 28 | |
Yes | 594 | 72 | 359 | 72 | 83 | 66 | 93 | 79 | 59 | 72 | |
Two-year overall survival | .17 | ||||||||||
No/missing | 341 | 41 | 212 | 43 | 59 | 47 | 42 | 36 | 28 | 34 | |
Yes | 481 | 59 | 285 | 57 | 67 | 53 | 75 | 64 | 54 | 66 |
P < .20 is suppressed.