Table 1. Summary statistics for... | American Society of Hematology

Table 1.

Summary statistics for platelet-reactivity genome wide association study (<5 × 10⁻⁸)

Phenotype	Variant ID	Chr	Position	Predicted consequence	Ref. allele	Alt. allele	Alt. allele frequency	n	Effect size (SD/ALT allele)	SE (SD/ALT alleles)	P	Nearest gene
ADP	rs12566888	1	156 869 047	Intronic variant	G	T	0.09	1341	−0.391	0.0706	3.184 × 10⁻⁸	PEAR1
ADP	rs7624918	3	56 901 292	Intronic variant	C	T	0.34	1341	0.284	0.0434	5.75 × 10⁻¹¹	ARHGEF3
CRP-XL	rs1613662	19	55 536 595	Nonsynonymous variant c.655C>T p.(Pro219Ser)	G	A	0.83	1329	0.923	0.0432	5.01 × 10⁻¹⁰¹	GP6
PAR-4	rs773902	19	17 000 632	Nonsynonymous variant c.358G>A p.(Ala120Thr)	G	A	0.20	550	0.515	0.0698	1.66 × 10⁻¹³	F2RL3
PAR-1	rs10886430	10	121 010 256	Intronic variant	A	G	0.13	546	1.09	0.0821	2.75 × 10⁻⁴⁰	GRK5

Phenotype	Variant ID	Chr	Position	Predicted consequence	Ref. allele	Alt. allele	Alt. allele frequency	n	Effect size (SD/ALT allele)	SE (SD/ALT alleles)	P	Nearest gene
ADP	rs12566888	1	156 869 047	Intronic variant	G	T	0.09	1341	−0.391	0.0706	3.184 × 10⁻⁸	PEAR1
ADP	rs7624918	3	56 901 292	Intronic variant	C	T	0.34	1341	0.284	0.0434	5.75 × 10⁻¹¹	ARHGEF3
CRP-XL	rs1613662	19	55 536 595	Nonsynonymous variant c.655C>T p.(Pro219Ser)	G	A	0.83	1329	0.923	0.0432	5.01 × 10⁻¹⁰¹	GP6
PAR-4	rs773902	19	17 000 632	Nonsynonymous variant c.358G>A p.(Ala120Thr)	G	A	0.20	550	0.515	0.0698	1.66 × 10⁻¹³	F2RL3
PAR-1	rs10886430	10	121 010 256	Intronic variant	A	G	0.13	546	1.09	0.0821	2.75 × 10⁻⁴⁰	GRK5

Coordinates are based on GRCh37. Predicted consequences are based on GP6 transcript NM_001083899.2 and PAR-4 transcript NM_003950.4

Alt., alternative; Chr, chromosome; Ref., reference.