Selected studies analyzing the coincidence of cytolysis and thrombotic events in patients with AIHA
| First author/reference . | AIHA type . | Rate of TE under best supportive therapy (number of patients) . | Signs for cytolysis during thromboembolic events . | Comment . |
|---|---|---|---|---|
| Pullarkat29 | Not defined | 27% (8 of 30) | TE associated with hemolysis (in 7 of 8) | Of 8 patients with TE
|
| Hendrick95 | w 80%, c 10%, m 10% | 21% (6 of 28) | 100% with signs of intravascular hemolysis (i.e, bilirubin, haptoglobin) | Of 6 patients with TE
|
| Baek94 | w 97%, c 3% | 16% (5 of 32) | >90% of patients with TE had intravascular hemolysis (LDH, bilirubin) | Most patients with AIHA are found to have SLE during follow-up |
| Barcellini86 | w 60%, c 27%, m 8%, a 5% | 11% (33 of 308) | TE associated with intravascular hemolysis (LDH) | Of 33 patients with TE
|
| Roumier96 | w 54%, m 46% | 20% (12 of 60) | TE occurred with active hemolysis in all (haptoglobin/LDH/bilirubin) | Of 12 patients with TE
|
| Lecouffe-Desprets85 | w 100% (inclusion criterium) | 20% (8 of 40) | TE associated with severe hemolytic flare’ | Of 8 patients with TE
|
| Prabhu87 | w 48%, c 46%, a 6% | 6% with life-threating TE (2 of 33) | NS | Of 2 patients with TE
|
| First author/reference . | AIHA type . | Rate of TE under best supportive therapy (number of patients) . | Signs for cytolysis during thromboembolic events . | Comment . |
|---|---|---|---|---|
| Pullarkat29 | Not defined | 27% (8 of 30) | TE associated with hemolysis (in 7 of 8) | Of 8 patients with TE
|
| Hendrick95 | w 80%, c 10%, m 10% | 21% (6 of 28) | 100% with signs of intravascular hemolysis (i.e, bilirubin, haptoglobin) | Of 6 patients with TE
|
| Baek94 | w 97%, c 3% | 16% (5 of 32) | >90% of patients with TE had intravascular hemolysis (LDH, bilirubin) | Most patients with AIHA are found to have SLE during follow-up |
| Barcellini86 | w 60%, c 27%, m 8%, a 5% | 11% (33 of 308) | TE associated with intravascular hemolysis (LDH) | Of 33 patients with TE
|
| Roumier96 | w 54%, m 46% | 20% (12 of 60) | TE occurred with active hemolysis in all (haptoglobin/LDH/bilirubin) | Of 12 patients with TE
|
| Lecouffe-Desprets85 | w 100% (inclusion criterium) | 20% (8 of 40) | TE associated with severe hemolytic flare’ | Of 8 patients with TE
|
| Prabhu87 | w 48%, c 46%, a 6% | 6% with life-threating TE (2 of 33) | NS | Of 2 patients with TE
|
Prevalence: 170 per 1 million.159 a, atypical; c, cold; m, mixed; NS, not specified; TE, thrombotic events; w, warm.