Comparison of patient demographic and clinical characteristics between the combination treatment group and sirolimus monotherapy group
| Parameters . | SIR plus PRE (n = 37) . | SIR (n = 36) . | P value . |
|---|---|---|---|
| Patients | |||
| Sex* | .729† | ||
| Female | 17 (45.9) | 18 (50) | |
| Age at discovery of tumor lesion (m) | .395‡ | ||
| Mean (range) | 1.5 (0.0-13.0) | 1.7 (0.0-20.0) | |
| Median (IQR) | 0.0 (0.0-1.8) | 0.0 (0.0-1.0) | |
| Age at onset of KMP (m) | .359§ | ||
| Mean (range) | 2.1 (0.0-13.0) | 2.0 (0.0-22.0) | |
| Median (IQR) | 1.3 (0.0-3.0) | 1.0 (0.0-2.0) | |
| Age at baseline (m) | .678§ | ||
| Mean (range) | 4.1 (0.3-15.0) | 4.2 (0.3-25) | |
| Median (IQR) | 3.0 (1.5-6.0) | 2.6 (1.5-4.4) | |
| Weight (kg) | .554§ | ||
| Mean (range) | 6.2 (3.5-12.2) | 6.2 (3.4-13.5) | |
| Median (IQR) | 6.0 (4.5-7.5) | 5.7 (4.5-7.0) | |
| Height (cm) | .800§ | ||
| Mean (range) | 58.6 (47.8-80.0) | 58.8 (47.7-92.5) | |
| Median (IQR) | 56.0 (51.7-63.5) | 56.3 (51.6-61.4) | |
| Prior treatment* | .562† | ||
| Yes | 11 (29.7) | 13 (36.1) | |
| KHE | |||
| Morphology* | .576ǁ | ||
| Superficial | 2 (5.4) | 3 (8.3) | |
| Mixed | 31 (83.8) | 30 (83.3) | |
| Deep | 4 (10.8) | 3 (8.3) | |
| Maximal tumor dimension (cm) | .599‡ | ||
| Mean (range) | 10.0 (4.0-21.0) | 10.8 (3.5-25.0) | |
| Median (IQR) | 9.0 (6.0-14.5) | 10.5 (6.0-13.8) | |
| Retroperitoneal or intrathoracic location* | 3 (8.1) | 2 (5.6) | 1.000§ |
| Bone and/or joint involvement* | 4 (10.8) | 5 (13.9) | .736§ |
| KMP | |||
| Duration of KMP (m) | .693‡ | ||
| Mean (range) | 2.0 (0.0-9.0) | 2.2 (0.0-17.5) | |
| Median (IQR) | 1.3 (0.5-2.4) | 1.7 (0.5-3.0) | |
| Platelet level (10 × 109/L) | .851‡ | ||
| Mean (range) | 15.6 (3.0-47.0) | 16.3 (3.0-46.0) | |
| Median (IQR) | 14.0 (9.0-21.0) | 13.0 (7.0-24.8) | |
| Platelet level <10 × 109/L* | 13 (35.1) | 13 (36.1) | .931† |
| Fibrinogen level (g/L) | .623‡ | ||
| Mean (range) | 0.8 (0.1-1.58) | 0.8 (0.2-1.4) | |
| Median (IQR) | 0.8 (0.4-1.2) | 0.9 (0.6-1.0) | |
| Fibrinogen level <0.5 g/L* | 10 (27.0) | 7 (19.4) | .443† |
| Hemoglobin (g/L) | .787‡ | ||
| Mean (range) | 97.1 (55.0-152.0) | 97.9 (59.0-156.0) | |
| Median (IQR) | 89.0 (79.5-113.0) | 98.0 (79.3-112.0) | |
| Hemoglobin <60 g/L* | 3 (8.1) | 1 (2.8) | .615ǁ |
| Parameters . | SIR plus PRE (n = 37) . | SIR (n = 36) . | P value . |
|---|---|---|---|
| Patients | |||
| Sex* | .729† | ||
| Female | 17 (45.9) | 18 (50) | |
| Age at discovery of tumor lesion (m) | .395‡ | ||
| Mean (range) | 1.5 (0.0-13.0) | 1.7 (0.0-20.0) | |
| Median (IQR) | 0.0 (0.0-1.8) | 0.0 (0.0-1.0) | |
| Age at onset of KMP (m) | .359§ | ||
| Mean (range) | 2.1 (0.0-13.0) | 2.0 (0.0-22.0) | |
| Median (IQR) | 1.3 (0.0-3.0) | 1.0 (0.0-2.0) | |
| Age at baseline (m) | .678§ | ||
| Mean (range) | 4.1 (0.3-15.0) | 4.2 (0.3-25) | |
| Median (IQR) | 3.0 (1.5-6.0) | 2.6 (1.5-4.4) | |
| Weight (kg) | .554§ | ||
| Mean (range) | 6.2 (3.5-12.2) | 6.2 (3.4-13.5) | |
| Median (IQR) | 6.0 (4.5-7.5) | 5.7 (4.5-7.0) | |
| Height (cm) | .800§ | ||
| Mean (range) | 58.6 (47.8-80.0) | 58.8 (47.7-92.5) | |
| Median (IQR) | 56.0 (51.7-63.5) | 56.3 (51.6-61.4) | |
| Prior treatment* | .562† | ||
| Yes | 11 (29.7) | 13 (36.1) | |
| KHE | |||
| Morphology* | .576ǁ | ||
| Superficial | 2 (5.4) | 3 (8.3) | |
| Mixed | 31 (83.8) | 30 (83.3) | |
| Deep | 4 (10.8) | 3 (8.3) | |
| Maximal tumor dimension (cm) | .599‡ | ||
| Mean (range) | 10.0 (4.0-21.0) | 10.8 (3.5-25.0) | |
| Median (IQR) | 9.0 (6.0-14.5) | 10.5 (6.0-13.8) | |
| Retroperitoneal or intrathoracic location* | 3 (8.1) | 2 (5.6) | 1.000§ |
| Bone and/or joint involvement* | 4 (10.8) | 5 (13.9) | .736§ |
| KMP | |||
| Duration of KMP (m) | .693‡ | ||
| Mean (range) | 2.0 (0.0-9.0) | 2.2 (0.0-17.5) | |
| Median (IQR) | 1.3 (0.5-2.4) | 1.7 (0.5-3.0) | |
| Platelet level (10 × 109/L) | .851‡ | ||
| Mean (range) | 15.6 (3.0-47.0) | 16.3 (3.0-46.0) | |
| Median (IQR) | 14.0 (9.0-21.0) | 13.0 (7.0-24.8) | |
| Platelet level <10 × 109/L* | 13 (35.1) | 13 (36.1) | .931† |
| Fibrinogen level (g/L) | .623‡ | ||
| Mean (range) | 0.8 (0.1-1.58) | 0.8 (0.2-1.4) | |
| Median (IQR) | 0.8 (0.4-1.2) | 0.9 (0.6-1.0) | |
| Fibrinogen level <0.5 g/L* | 10 (27.0) | 7 (19.4) | .443† |
| Hemoglobin (g/L) | .787‡ | ||
| Mean (range) | 97.1 (55.0-152.0) | 97.9 (59.0-156.0) | |
| Median (IQR) | 89.0 (79.5-113.0) | 98.0 (79.3-112.0) | |
| Hemoglobin <60 g/L* | 3 (8.1) | 1 (2.8) | .615ǁ |