Multivariate model for disease-free survival. The prospective selection of haploidentical donors may include consideration for the characteristics that most strongly influence disease-free survival. Estimates of disease-free survival may be calculated for a given patient based on patient and donor characteristics shown below (http://haplodonorselector.b12x.org/v1.0/)
| Characteristic . | N . | Hazard ratio (95% confidence interval; P) . |
|---|---|---|
| HLA-B leader match status | [global P = .01] | |
| Leader-matched | 856 | 1.0 |
| Leader-mismatched | 545 | 1.20 (1.04-1.37; .01) |
| HLA-DRB1/DQB1 match status* | [global P = .003] | |
| Mismatch/mismatch | 959 | 1.0 |
| Mismatch/match | 228 | 0.80 (0.67-0.95; .01) |
| Match/mismatch | 48 | 1.30 (0.95-1.78; .10) |
| Match/match | 166 | 1.32 (1.05-1.65; .02) |
| HLA-DPB1 TCE status | [global P = .04] | |
| No nonpermissive GVH mismatch | 562 | 1.0 |
| Nonpermissive GVH mismatch | 101 | 0.72 (0.56-0.93; .01) |
| Missing data | 738 | 0.97 (0.85-1.12; .71) |
| Patient/donor CMV serostatus | [global P = .005] | |
| Positive/positive | 596 | 1.0 |
| Positive/negative | 116 | 1.00 (0.78-1.28; .98) |
| Negative/positive | 393 | 1.10 (0.93-1.30; .25) |
| Negative/negative | 286 | 0.79 (0.61-1.03; .08) |
| Missing data | 10 | 1.30 (0.77-2.21; .33) |
| Patient comorbidity index | [global P < .0001] | |
| 0 | 298 | 1.0 |
| 1 | 205 | 1.21 (0.96-1.52; .11) |
| 2 | 209 | 1.24 (0.98-1.58; .07) |
| ≥3 | 689 | 1.54 (1.27-1.87; <.0001) |
| Patient age (years) | [global P = .0001] | |
| 0-18 | 121 | 1.0 |
| 19-29 | 155 | 1.03 (0.73-1.46; .85) |
| 30-39 | 128 | 0.99 (0.70-1.41; .97) |
| 40-49 | 191 | 0.90 (0.64-1.26; .54) |
| 50-59 | 307 | 1.07 (0.74-1.53; .73) |
| ≥60 | 499 | 1.41 (0.94-2.11; .09) |
| Characteristic . | N . | Hazard ratio (95% confidence interval; P) . |
|---|---|---|
| HLA-B leader match status | [global P = .01] | |
| Leader-matched | 856 | 1.0 |
| Leader-mismatched | 545 | 1.20 (1.04-1.37; .01) |
| HLA-DRB1/DQB1 match status* | [global P = .003] | |
| Mismatch/mismatch | 959 | 1.0 |
| Mismatch/match | 228 | 0.80 (0.67-0.95; .01) |
| Match/mismatch | 48 | 1.30 (0.95-1.78; .10) |
| Match/match | 166 | 1.32 (1.05-1.65; .02) |
| HLA-DPB1 TCE status | [global P = .04] | |
| No nonpermissive GVH mismatch | 562 | 1.0 |
| Nonpermissive GVH mismatch | 101 | 0.72 (0.56-0.93; .01) |
| Missing data | 738 | 0.97 (0.85-1.12; .71) |
| Patient/donor CMV serostatus | [global P = .005] | |
| Positive/positive | 596 | 1.0 |
| Positive/negative | 116 | 1.00 (0.78-1.28; .98) |
| Negative/positive | 393 | 1.10 (0.93-1.30; .25) |
| Negative/negative | 286 | 0.79 (0.61-1.03; .08) |
| Missing data | 10 | 1.30 (0.77-2.21; .33) |
| Patient comorbidity index | [global P < .0001] | |
| 0 | 298 | 1.0 |
| 1 | 205 | 1.21 (0.96-1.52; .11) |
| 2 | 209 | 1.24 (0.98-1.58; .07) |
| ≥3 | 689 | 1.54 (1.27-1.87; <.0001) |
| Patient age (years) | [global P = .0001] | |
| 0-18 | 121 | 1.0 |
| 19-29 | 155 | 1.03 (0.73-1.46; .85) |
| 30-39 | 128 | 0.99 (0.70-1.41; .97) |
| 40-49 | 191 | 0.90 (0.64-1.26; .54) |
| 50-59 | 307 | 1.07 (0.74-1.53; .73) |
| ≥60 | 499 | 1.41 (0.94-2.11; .09) |
Match/mismatch relative to match/match: HR 0.98 (0.70-1.39; .93); mismatch/match relative to match/match: HR 0.61 (0.46-0.80; .0004); and mismatch/match relative to match/mismatch: HR 0.62 (0.43-0.88; .007).