Table 2. Similarities in HCMV and MCMV... | American Society of Hematology

Table 2.

Similarities in HCMV and MCMV

Feature	HCMV	MCMV
Prevalence	Worldwide seroprevalence: 45% to 100%⁵⁰	Seroprevalence: 61.7%, 79.4%, and 90%^118-120
Multiple viral strains	Diverse viral isolates identified^121,122	Diverse viral isolates identified^120,123
Life cycle	Primary, chronic, and latent infection	Primary, chronic, and latent infection
Organ disease	Characteristic sites: lung, liver, and GI tract	Characteristic sites: lung, liver, and GI tract
Unique immune responses	NK-cell memory: NKG2C⁺ NK cells^64,65	NK-cell memory: Ly49H⁺ NK cells^62,63
	CD8⁺ T-cell memory inflation^124-126	CD8⁺ T-cell memory inflation^126,127
Resistance to antiviral drugs	Mutations in HCMV DNA polymerase and UL97^128-130	Mutations in MCMV DNA polymerase and M97¹³⁰

Feature	HCMV	MCMV
Prevalence	Worldwide seroprevalence: 45% to 100%⁵⁰	Seroprevalence: 61.7%, 79.4%, and 90%^118-120
Multiple viral strains	Diverse viral isolates identified^121,122	Diverse viral isolates identified^120,123
Life cycle	Primary, chronic, and latent infection	Primary, chronic, and latent infection
Organ disease	Characteristic sites: lung, liver, and GI tract	Characteristic sites: lung, liver, and GI tract
Unique immune responses	NK-cell memory: NKG2C⁺ NK cells^64,65	NK-cell memory: Ly49H⁺ NK cells^62,63
	CD8⁺ T-cell memory inflation^124-126	CD8⁺ T-cell memory inflation^126,127
Resistance to antiviral drugs	Mutations in HCMV DNA polymerase and UL97^128-130	Mutations in MCMV DNA polymerase and M97¹³⁰

GI, gastrointestinal.