Immune deficiency states and impact on viral reactivation after SCT
| . | Degree of immune deficiency . | ||
|---|---|---|---|
| . | Low . | Moderate . | High . |
| Severity of immune deficiency after SCT | |||
| Autologous | ✓ | — | — |
| Allogeneic | — | — | — |
| MSD | — | ✓ | — |
| MUD | — | ✓ | — |
| Haplo/HLA mismatched | — | — | ✓ |
| CBT | — | — | ✓ |
| Pan T-cell depletion | — | — | ✓ |
| GVHD on high dose steroids | — | — | ✓ |
| Virus type and risk of reactivation | |||
| HSV | ✓ | ✓ | ✓ |
| VZV | ✓ | ✓ | ✓ |
| CMV | — | ✓ | ✓ |
| HHV6 | — | ✓ | ✓ |
| BKV | — | ✓ | ✓ |
| Adenovirus | — | — | ✓ |
| EBV | — | — | ✓ |
| . | Degree of immune deficiency . | ||
|---|---|---|---|
| . | Low . | Moderate . | High . |
| Severity of immune deficiency after SCT | |||
| Autologous | ✓ | — | — |
| Allogeneic | — | — | — |
| MSD | — | ✓ | — |
| MUD | — | ✓ | — |
| Haplo/HLA mismatched | — | — | ✓ |
| CBT | — | — | ✓ |
| Pan T-cell depletion | — | — | ✓ |
| GVHD on high dose steroids | — | — | ✓ |
| Virus type and risk of reactivation | |||
| HSV | ✓ | ✓ | ✓ |
| VZV | ✓ | ✓ | ✓ |
| CMV | — | ✓ | ✓ |
| HHV6 | — | ✓ | ✓ |
| BKV | — | ✓ | ✓ |
| Adenovirus | — | — | ✓ |
| EBV | — | — | ✓ |
Haplo, haploidentical; MSD, matched sibling donor; MUD, matched unrelated donor; VZV, varicella zoster virus.