Multivariate analysis for NRM of clinical characteristics and lung and cardiac function parameters in patients conditioned with BEAM or high-dose melphalan prior to auto-HSCT
| Variables . | BEAM . | High-dose melphalan . | ||||
|---|---|---|---|---|---|---|
| n . | SHR (95% CI) . | P . | n . | SHR (95% CI) . | P . | |
| DLCOcSB ≤ 60% of predicted | 37 | 6.50 (2.35-17.9) | .001 | 31 | 0.71 (0.11- 4.4) | .71 |
| Solid tumor in previous diagnosis | 32 | 4.83 (1.73-13.4) | .003 | |||
| Hematological disease prior to current diagnosis | 32 | 3.33 (1.03-10.8) | .04 | |||
| Lung disease prior to auto-HSCT | 33 | 3.88 (1.12-7.37) | .03 | |||
| FEV1 initial ≤ 70% of predicted | 41 | 2.15 (0.94-4.92) | .07 | |||
| Age > 70 y | 23 | 1.12 (0.23-5.40) | .89 | 126* | 3.1 (0.76- 12.6)* | .10* |
| KPS ≤ 80% | 89 | 1.53 (0.66-3.54) | .32 | 109 | 1.59 (0.44- 5.68) | .47 |
| HCT-CI score ≥ 4 | 137 | 1.10 (0.66-2.28) | .85 | 56 | 4.4 (0.98-19.6) | .05 |
| Variables . | BEAM . | High-dose melphalan . | ||||
|---|---|---|---|---|---|---|
| n . | SHR (95% CI) . | P . | n . | SHR (95% CI) . | P . | |
| DLCOcSB ≤ 60% of predicted | 37 | 6.50 (2.35-17.9) | .001 | 31 | 0.71 (0.11- 4.4) | .71 |
| Solid tumor in previous diagnosis | 32 | 4.83 (1.73-13.4) | .003 | |||
| Hematological disease prior to current diagnosis | 32 | 3.33 (1.03-10.8) | .04 | |||
| Lung disease prior to auto-HSCT | 33 | 3.88 (1.12-7.37) | .03 | |||
| FEV1 initial ≤ 70% of predicted | 41 | 2.15 (0.94-4.92) | .07 | |||
| Age > 70 y | 23 | 1.12 (0.23-5.40) | .89 | 126* | 3.1 (0.76- 12.6)* | .10* |
| KPS ≤ 80% | 89 | 1.53 (0.66-3.54) | .32 | 109 | 1.59 (0.44- 5.68) | .47 |
| HCT-CI score ≥ 4 | 137 | 1.10 (0.66-2.28) | .85 | 56 | 4.4 (0.98-19.6) | .05 |
Multivariate analysis following backward selection was performed using the Fine and Gray regression model in the presence of competing risks and using age, HCT-CI score, and KPS as hypothesis covariates.
FEV1, forced expiratory volume in 1 second.
Age > 60 years.