Clinical and lung function parameters associated with OS in multivariate Cox regression analysis after conditioning using BEAM or high-dose melphalan
| Variables . | BEAM . | High-dose melphalan . | ||||
|---|---|---|---|---|---|---|
| Patients, n . | HR (95% CI) . | P . | Patients, n . | HR (95% CI) . | P . | |
| DLCOcSB ≤ 60 % of predicted | 37 | 2.47 (1.47-4.13) | .001 | 31 | 1.74 (0.92-3.28) | .08 |
| Age > 70 y | 23 | 2.13 (1.07-4.22) | .03 | 126* | 2.05 (1.28-3.26)* | .003* |
| KPS ≤ 80% | 89 | 1.89 (1.20-2.97) | .005 | 109 | 1.28 (0.81-2.03) | .28 |
| HCT-CI score ≥ 4 | 137 | 1.46 (0.94-2.28) | .09 | 56 | 2.11 (1.26-3.53) | .004 |
| Progressive disease status prior to auto-HSCT | 28 | 7.18 (4.14-12.4) | .001 | 18 | 1.07 (0.46-2.50) | .88 |
| Variables . | BEAM . | High-dose melphalan . | ||||
|---|---|---|---|---|---|---|
| Patients, n . | HR (95% CI) . | P . | Patients, n . | HR (95% CI) . | P . | |
| DLCOcSB ≤ 60 % of predicted | 37 | 2.47 (1.47-4.13) | .001 | 31 | 1.74 (0.92-3.28) | .08 |
| Age > 70 y | 23 | 2.13 (1.07-4.22) | .03 | 126* | 2.05 (1.28-3.26)* | .003* |
| KPS ≤ 80% | 89 | 1.89 (1.20-2.97) | .005 | 109 | 1.28 (0.81-2.03) | .28 |
| HCT-CI score ≥ 4 | 137 | 1.46 (0.94-2.28) | .09 | 56 | 2.11 (1.26-3.53) | .004 |
| Progressive disease status prior to auto-HSCT | 28 | 7.18 (4.14-12.4) | .001 | 18 | 1.07 (0.46-2.50) | .88 |
Multivariate analysis was performed with the Cox proportional-hazards regression model using parameters influencing outcome and DLCOcSB ≤ 60% of predicted as hypothesis covariate.
Age > 60 years.