Pretreatment characteristics of PTPN11mut patients according to the location of the mutation within the gene
| Characteristic . | PTPN11mut N-SH2 (n = 86) . | PTPN11mut phosphatase (n = 45) . | P* . |
|---|---|---|---|
| Age, y | .46 | ||
| Median | 54 | 51 | |
| Range | 18-82 | 23-79 | |
| Sex, n (%) | .46 | ||
| Male | 41 (48) | 25 (56) | |
| Female | 45 (52) | 20 (44) | |
| Race, n (%) | 1.00 | ||
| White | 76 (88) | 39 (89) | |
| Non-white | 10 (12) | 5 (11) | |
| Hemoglobin, g/dL | .98 | ||
| Median | 9.1 | 9.2 | |
| Range | 5.7-13.8 | 6.0-15.0 | |
| Platelet count, ×109/L | .22 | ||
| Median | 72 | 82 | |
| Range | 13-648 | 17-415 | |
| WBC count, ×109/L | .89 | ||
| Median | 31.3 | 31.6 | |
| Range | 1.5-355.0 | 1.4-135.0 | |
| % Blood blasts | .22 | ||
| Median | 52 | 42 | |
| Range | 0-97 | 0-88 | |
| % BM blasts | .03 | ||
| Median | 65 | 52 | |
| Range | 12-99 | 15-90 | |
| Extramedullary involvement, n (%) | 27 (33) | 15 (34) | 1.00 |
| Characteristic . | PTPN11mut N-SH2 (n = 86) . | PTPN11mut phosphatase (n = 45) . | P* . |
|---|---|---|---|
| Age, y | .46 | ||
| Median | 54 | 51 | |
| Range | 18-82 | 23-79 | |
| Sex, n (%) | .46 | ||
| Male | 41 (48) | 25 (56) | |
| Female | 45 (52) | 20 (44) | |
| Race, n (%) | 1.00 | ||
| White | 76 (88) | 39 (89) | |
| Non-white | 10 (12) | 5 (11) | |
| Hemoglobin, g/dL | .98 | ||
| Median | 9.1 | 9.2 | |
| Range | 5.7-13.8 | 6.0-15.0 | |
| Platelet count, ×109/L | .22 | ||
| Median | 72 | 82 | |
| Range | 13-648 | 17-415 | |
| WBC count, ×109/L | .89 | ||
| Median | 31.3 | 31.6 | |
| Range | 1.5-355.0 | 1.4-135.0 | |
| % Blood blasts | .22 | ||
| Median | 52 | 42 | |
| Range | 0-97 | 0-88 | |
| % BM blasts | .03 | ||
| Median | 65 | 52 | |
| Range | 12-99 | 15-90 | |
| Extramedullary involvement, n (%) | 27 (33) | 15 (34) | 1.00 |
BM, bone marrow; WBC, white blood cell.
P values are from Fisher’s exact test for discrete variables and from the Wilcoxon rank sum test for continuous variables.