Summary of the metabolomic differences seen in cGVHD and late aGVHD
| Name . | Type of metabolite . | D100 before onset of cGVHD . | Biologic analysis at the onset of cGVHD . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Late aGVHD (Figure 2) . | Mild to severe cGVHD (Figure 1A) . | Moderate to severe cGVHD (Figure 1B) . | cGVHD compared no cGVHD or late aGVHD . | Clinical presentation . | ||||||
| Overall (Figure 3A) . | Moderate to severe (Figure 3B) . | No previous aGVHD or cGVHD (Figure 3C) . | De novo cGVHD vs other cGVHD (Figure 7A) . | Progressive cGVHD vs other cGVHD (Figure 7B) . | Pulmonary cGVHD vs other cGVHD (Figure 7C) . | |||||
| α-Ketoglutaric acid | Organic acids | ++ | ++ | +++ | +++ | +++ | ||||
| Fumaric acid | ++ | ++ | ||||||||
| Citric acid | ---- | |||||||||
| Isobutyric acid | ---- | |||||||||
| Methylmalonic acid | ---- | |||||||||
| p-Hydroxyhippuric acid | --- | -- | --- | |||||||
| Indole acetic acid | + | |||||||||
| Glutamic acid | Amino acids | +++ | +++ | +++ | + | |||||
| Kynurenine | Amino acid-related | +++ | +++ | +++ | ||||||
| PC36:0AE | Phosphatidyl cholines | + | ||||||||
| PC36:6AA | + | |||||||||
| C5OH | Medium-chain fatty acids | +++ | ||||||||
| C10:2 | ----- | |||||||||
| C12 | -- | |||||||||
| C9 | --- | --- | --- | |||||||
| Serotonin | Biogenic amine | -- | ||||||||
| Acetyl-ornithine | -- | --- | -- | |||||||
| Creatine | + | |||||||||
| LYSOC14:0 | Lysophosphatidyl cholines | + | ||||||||
| 18:0SM | Sphingolipid | +++ | ++++ | |||||||
| Name . | Type of metabolite . | D100 before onset of cGVHD . | Biologic analysis at the onset of cGVHD . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Late aGVHD (Figure 2) . | Mild to severe cGVHD (Figure 1A) . | Moderate to severe cGVHD (Figure 1B) . | cGVHD compared no cGVHD or late aGVHD . | Clinical presentation . | ||||||
| Overall (Figure 3A) . | Moderate to severe (Figure 3B) . | No previous aGVHD or cGVHD (Figure 3C) . | De novo cGVHD vs other cGVHD (Figure 7A) . | Progressive cGVHD vs other cGVHD (Figure 7B) . | Pulmonary cGVHD vs other cGVHD (Figure 7C) . | |||||
| α-Ketoglutaric acid | Organic acids | ++ | ++ | +++ | +++ | +++ | ||||
| Fumaric acid | ++ | ++ | ||||||||
| Citric acid | ---- | |||||||||
| Isobutyric acid | ---- | |||||||||
| Methylmalonic acid | ---- | |||||||||
| p-Hydroxyhippuric acid | --- | -- | --- | |||||||
| Indole acetic acid | + | |||||||||
| Glutamic acid | Amino acids | +++ | +++ | +++ | + | |||||
| Kynurenine | Amino acid-related | +++ | +++ | +++ | ||||||
| PC36:0AE | Phosphatidyl cholines | + | ||||||||
| PC36:6AA | + | |||||||||
| C5OH | Medium-chain fatty acids | +++ | ||||||||
| C10:2 | ----- | |||||||||
| C12 | -- | |||||||||
| C9 | --- | --- | --- | |||||||
| Serotonin | Biogenic amine | -- | ||||||||
| Acetyl-ornithine | -- | --- | -- | |||||||
| Creatine | + | |||||||||
| LYSOC14:0 | Lysophosphatidyl cholines | + | ||||||||
| 18:0SM | Sphingolipid | +++ | ++++ | |||||||
+, P ≤ .05; ++, P ≤ .001; +++, P ≤ .0001; –, P ≤ .05; ––, P ≤ .001; –––, P ≤ .0001.