Predictors of 1-y OS
| . | Univariate . | Multivariate . | |||||
|---|---|---|---|---|---|---|---|
| Characteristics . | Adults, n (%) N = 585 . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Toxicity (time dependent) | 38 | 2.8 | 1.7-4.5 | <.001 | 2.7 | 1.7-4.4 | <.001 |
| Age, y Age >55 Age ≤55 | 309 (53) 276 (47) | 1.1 1.0 | 0.8-1.5 | .6 | — | — | — |
| Disease status Active Remission | 356 61) 229 (39) | 1.9 1.0 | 1.4-2.8 | <.001 | 1.9 | 1.3-2.8 | <.001 |
| GVHD prophylaxis PTCy-based Non-PTCy | 272 (46) 313 (53) | 0.6 1.0 | 0.4-0.8 | .001 | 0.5 | 0.4-0.7 | <.001 |
| Preparative regimen Reduced intensity Myeloablative | 201 (34) 384 (66) | 1.3 1.0 | 0.9-1.8 | .08 | — | — | — |
| Stem cell source Peripheral blood Bone marrow | 475 (81) 110 (19) | 0.7 1.0 | 0.5-0.9 | .04 | — | — | — |
| History of HTN Yes No | 235 (40) 350 (60) | 1.5 1.0 | 1.1-2.1 | .008 | — | — | — |
| History of hyperlipidemia Yes No | 115 (20) 470 (80) | 1.05 1.0 | 0.7-1.5 | .8 | — | — | — |
| Smoker Yes No | 227 (39) 356 (61) | 1.4 1.0 | 1.03-1.9 | .03 | — | — | — |
| Karnovsky Performance Scale <90 ≥90 | 230 (39) 287 (49) | 1.4 1.0 | 1.03-2.1 | .03 | — | — | — |
| HCT-CI | |||||||
| >3 | 195 (33) | 1.9 | 1.4-2.6 | <.001 | 1.8 | 1.3-2.5 | <.001 |
| ≤3 | 390 (67) | 1.0 | — | — | — | ||
| . | Univariate . | Multivariate . | |||||
|---|---|---|---|---|---|---|---|
| Characteristics . | Adults, n (%) N = 585 . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Toxicity (time dependent) | 38 | 2.8 | 1.7-4.5 | <.001 | 2.7 | 1.7-4.4 | <.001 |
| Age, y Age >55 Age ≤55 | 309 (53) 276 (47) | 1.1 1.0 | 0.8-1.5 | .6 | — | — | — |
| Disease status Active Remission | 356 61) 229 (39) | 1.9 1.0 | 1.4-2.8 | <.001 | 1.9 | 1.3-2.8 | <.001 |
| GVHD prophylaxis PTCy-based Non-PTCy | 272 (46) 313 (53) | 0.6 1.0 | 0.4-0.8 | .001 | 0.5 | 0.4-0.7 | <.001 |
| Preparative regimen Reduced intensity Myeloablative | 201 (34) 384 (66) | 1.3 1.0 | 0.9-1.8 | .08 | — | — | — |
| Stem cell source Peripheral blood Bone marrow | 475 (81) 110 (19) | 0.7 1.0 | 0.5-0.9 | .04 | — | — | — |
| History of HTN Yes No | 235 (40) 350 (60) | 1.5 1.0 | 1.1-2.1 | .008 | — | — | — |
| History of hyperlipidemia Yes No | 115 (20) 470 (80) | 1.05 1.0 | 0.7-1.5 | .8 | — | — | — |
| Smoker Yes No | 227 (39) 356 (61) | 1.4 1.0 | 1.03-1.9 | .03 | — | — | — |
| Karnovsky Performance Scale <90 ≥90 | 230 (39) 287 (49) | 1.4 1.0 | 1.03-2.1 | .03 | — | — | — |
| HCT-CI | |||||||
| >3 | 195 (33) | 1.9 | 1.4-2.6 | <.001 | 1.8 | 1.3-2.5 | <.001 |
| ≤3 | 390 (67) | 1.0 | — | — | — | ||