Table 2. Findings of 3 studies... | American Society of Hematology

Table 2.

Findings of 3 studies evaluating outcomes based on IBW

Reference	Study design (age, years)	n	Intervention	Mean (range)				Achieved peak FVIII level or expected recovery or IVR
Reference	Study design (age, years)	n	Intervention	ABW (kg)	BMI	IBW	Peak FVIII level or expected recovery or IVR	Achieved peak FVIII level or expected recovery or IVR
Grahamet al¹⁰	Retrospective (median, 33; range, 25-47)	6	rFVIII 50 IU/kg by IBW	116 (91-151)	36.0 (30.0-45.8)	74.4 (67.0–84.5)	Peak FVIII level 100% (78-123)	83% (5 of 6)^a
Blair et al¹¹	Prospective crossover (median, 21.5; range, 12-53)	16	FVIII 50 IU/kg (±20%) by both ABW and IBW	NR	Median, 33.1 (25.6-41.8)	NR	ABW, 140% expected recovery (83-196); IBW, 100% expected recovery (56-137)	ABW, 94% (15 of 16)^b; IBW, 87.5% (14 of 16)^b
Seaman et al¹²	Prospective crossover (mean, 34.6 ± 11.3)	19	A dose of rFVIII based on ABW, IBW, and LBM and an IVR of 2.0	93.0 ± 13.6	29.2 ± 3.5 (Max, 38.3)	73.6 ± 6.3	ABW: IVR, 2.46; IBW: IVR, 2.29; LBM: IVR, 2.22	ABW, 31.1%^c; IBW, 49.0%^c; LBM, 44.2%^c

Reference	Study design (age, years)	n	Intervention	Mean (range)				Achieved peak FVIII level or expected recovery or IVR
Reference	Study design (age, years)	n	Intervention	ABW (kg)	BMI	IBW	Peak FVIII level or expected recovery or IVR	Achieved peak FVIII level or expected recovery or IVR
Grahamet al¹⁰	Retrospective (median, 33; range, 25-47)	6	rFVIII 50 IU/kg by IBW	116 (91-151)	36.0 (30.0-45.8)	74.4 (67.0–84.5)	Peak FVIII level 100% (78-123)	83% (5 of 6)^a
Blair et al¹¹	Prospective crossover (median, 21.5; range, 12-53)	16	FVIII 50 IU/kg (±20%) by both ABW and IBW	NR	Median, 33.1 (25.6-41.8)	NR	ABW, 140% expected recovery (83-196); IBW, 100% expected recovery (56-137)	ABW, 94% (15 of 16)^b; IBW, 87.5% (14 of 16)^b
Seaman et al¹²	Prospective crossover (mean, 34.6 ± 11.3)	19	A dose of rFVIII based on ABW, IBW, and LBM and an IVR of 2.0	93.0 ± 13.6	29.2 ± 3.5 (Max, 38.3)	73.6 ± 6.3	ABW: IVR, 2.46; IBW: IVR, 2.29; LBM: IVR, 2.22	ABW, 31.1%^c; IBW, 49.0%^c; LBM, 44.2%^c

Above expected peak FVIII level of 100% or within 10% below expected peak FVIII level.

Above expected recovery or within 10% below expected recovery.

Within 10% of targeted IVR of 2.00.

LBW, lean body weight.