Endovascular therapy in acute CVT
| Trial . | Study design . | No of patients . | Intervention . | Results . | Limitations . |
|---|---|---|---|---|---|
| Coutinho et al36 (TO-ACT trial) | Randomized, controlled | 67 | Endovascular treatment in patients Inclusion criteria: ≥1 Risk factor for clinical deterioration (coma, mental status changes, CVT in deep venous system, intracerebral hemorrhage) | Stopped prematurely for futility | Small sample size |
| Dentali et al37 | Systematic review of 15 studies | 156 | Mechanical thrombectomy/thrombolysis | Death rate 9% Major bleeding 10% with local thrombolysis 8% intracranial hemorrhage 58% fatal | |
| Siddiqui et al40 | Systematic review of 42 studies | 185 | Mechanical thrombectomy/thrombolysis (71%) 60% pretreatment intracranial hemorrhage 47% stupor, coma | 84% good outcome 12% mortality 10% new/worsened intracerebral hemorrhage 95% recanalization rate | Concern for bias as the studies were not blinded |
| Trial . | Study design . | No of patients . | Intervention . | Results . | Limitations . |
|---|---|---|---|---|---|
| Coutinho et al36 (TO-ACT trial) | Randomized, controlled | 67 | Endovascular treatment in patients Inclusion criteria: ≥1 Risk factor for clinical deterioration (coma, mental status changes, CVT in deep venous system, intracerebral hemorrhage) | Stopped prematurely for futility | Small sample size |
| Dentali et al37 | Systematic review of 15 studies | 156 | Mechanical thrombectomy/thrombolysis | Death rate 9% Major bleeding 10% with local thrombolysis 8% intracranial hemorrhage 58% fatal | |
| Siddiqui et al40 | Systematic review of 42 studies | 185 | Mechanical thrombectomy/thrombolysis (71%) 60% pretreatment intracranial hemorrhage 47% stupor, coma | 84% good outcome 12% mortality 10% new/worsened intracerebral hemorrhage 95% recanalization rate | Concern for bias as the studies were not blinded |