Table 1. lncRNAs involved in genome... | American Society of Hematology

Table 1.

lncRNAs involved in genome topology

Name	Role in genome organization	Function	Reference
HOTTIP	Topological organization of posterior HOXA and canonical Wnt/β-catenin target genes	HSC self-renewal AML leukemogenesis	7
Xist	Scaffold and 3D topology for PRC2/H3K27me3	X-inactivation	33
APOLO	R-loop–mediated decoy of PRC1 and chromatin loop modulation	Gene transcription root development	25
Firre	Spatial organization of multiple chromosomal regions	Adipogenesis ESC pluripotency	67
HOXBLINC	3D organization of anterior HOXB genes	Hemagiogenic mesoderm NPM1^C+-driven AML	3, 44
PAIR	PAIR elements/Eμ long-range interactions	VDJ recombination	68
MYMLR	Long-range enhancer/promoter interaction	MYC transcription	69
H19X	Long-range enhancer/promoter interaction	Transcription silencing	70
p53BER eRNA	p53BER and p53 target gene long-range contacts	p53-driven transcription	23
ARIEL eRNA	Long-range enhancer and promoter interaction	Proto-oncogene transcription T-ALL survival pathway	24

Name	Role in genome organization	Function	Reference
HOTTIP	Topological organization of posterior HOXA and canonical Wnt/β-catenin target genes	HSC self-renewal AML leukemogenesis	7
Xist	Scaffold and 3D topology for PRC2/H3K27me3	X-inactivation	33
APOLO	R-loop–mediated decoy of PRC1 and chromatin loop modulation	Gene transcription root development	25
Firre	Spatial organization of multiple chromosomal regions	Adipogenesis ESC pluripotency	67
HOXBLINC	3D organization of anterior HOXB genes	Hemagiogenic mesoderm NPM1^C+-driven AML	3, 44
PAIR	PAIR elements/Eμ long-range interactions	VDJ recombination	68
MYMLR	Long-range enhancer/promoter interaction	MYC transcription	69
H19X	Long-range enhancer/promoter interaction	Transcription silencing	70
p53BER eRNA	p53BER and p53 target gene long-range contacts	p53-driven transcription	23
ARIEL eRNA	Long-range enhancer and promoter interaction	Proto-oncogene transcription T-ALL survival pathway	24

ESC, embryonic stem cell; T-ALL, T-cell acute lymphoblastic leukemia.