SCT (AS) in WIHS is associated with increase in CD4 and decrease in CD8 over time
| Variable . | Effect at baseline visit . | Effect on change during follow-up . | ||
|---|---|---|---|---|
| β (95%CI) . | P . | β (95%CI) . | P . | |
| Viral load (natural log)* | ||||
| AS | −0.29 (–1.12 to 0.54) | .50 | −0.02 (–0.07 to 0.03) | .43 |
| Time from baseline visit, y | −0.11 (–0.14 to −0.08) | <.001 | NA | NA |
| CD4 (square root)† | ||||
| AS | 3.12 (0.92 to 5.41) | .006 | −0.12 (−0.22 to −0.01) | .036 |
| Time from baseline visit, mo | 0.14 (0.10-0.17) | <.001 | NA | NA |
| CD8 (square root)‡ | ||||
| AS | 0.06 (–1.94 to 2.06) | .95 | −0.24 (–0.32 to −0.15) | <.001 |
| Time from baseline visit, mo | −0.06 (–0.09 to −0.03) | <.001 | NA | NA |
| CD4/CD8§ | ||||
| AS | 0.05 (–0.10 to 0.19) | .53 | 0.009 (0.005 to 0.014) | <.001 |
| Time from baseline visit, mo | 0.012 (0.011 to 0.013) | <.001 | NA | NA |
| Variable . | Effect at baseline visit . | Effect on change during follow-up . | ||
|---|---|---|---|---|
| β (95%CI) . | P . | β (95%CI) . | P . | |
| Viral load (natural log)* | ||||
| AS | −0.29 (–1.12 to 0.54) | .50 | −0.02 (–0.07 to 0.03) | .43 |
| Time from baseline visit, y | −0.11 (–0.14 to −0.08) | <.001 | NA | NA |
| CD4 (square root)† | ||||
| AS | 3.12 (0.92 to 5.41) | .006 | −0.12 (−0.22 to −0.01) | .036 |
| Time from baseline visit, mo | 0.14 (0.10-0.17) | <.001 | NA | NA |
| CD8 (square root)‡ | ||||
| AS | 0.06 (–1.94 to 2.06) | .95 | −0.24 (–0.32 to −0.15) | <.001 |
| Time from baseline visit, mo | −0.06 (–0.09 to −0.03) | <.001 | NA | NA |
| CD4/CD8§ | ||||
| AS | 0.05 (–0.10 to 0.19) | .53 | 0.009 (0.005 to 0.014) | <.001 |
| Time from baseline visit, mo | 0.012 (0.011 to 0.013) | <.001 | NA | NA |
Results were calculated from a mixed effect model (with random coefficient for each study subject). Interaction between AS and duration was reported as effect on change during follow-up.
Variables in model: nucleoside reverse-transcriptase inhibitors (NRTI), non-nucleoside reverse transcriptase inhibitors (NNRTI), protease inhibitor (PI), age at visit, any drug, and interaction of genotype with PI.
Variables in model: NRTI, NNRTI, PI, any drug, and interaction of genotype with NRTI.
Variables in model: NNRTI and PI.
Variables in model: NRTI, NNRTI, and interaction of genotype with NNRTI.