Conserved sequences of CD63 IREs in various species
| Conserved CD63 IREs species . | Common name . | Predicted sequences . | Free energy (kcal/mol) . | IRE motif classification . |
|---|---|---|---|---|
| Homo sapiens | Human | GAGGGGGCUUGCACAGAGUUGGAGCCAGAGG | −2.3 | Typical |
| Pan paniscus | Bonobo; pygmy chimpanzee | GAGGGGGCTTGCACAGAGTTGGAGCCAGAGG | −2.3 | Typical |
| Pan troglodytes | Chimpanzee | GAGGGGGCUUGCACAGAGUUGGAGCCAGAGG | −2.3 | Typical |
| Gorilla gorilla | Western gorilla | GACGGGGCUUGCACAGAGUUGGAGCCAGAGG | −2.3 | Typical |
| Theropithecus gelada | Gelada; gelada baboon | UUUCCGGGUGGGAGGGGCCGGGAAUCG | −4.3 | SELEX |
| Bos taurus | Cattle | CCCCCCUCAUCCGGGGAGGGGGGUAAUAUAC | −3.4 | SELEX |
| Sus scrofa | Pig | CCUGAGCCGCGGCGGGAGUGCAGCGCACAGC | −8.4 | SELEX |
| Peromyscus leucopus | White-footed mouse | CCUGAGCCGCGGCGGGAGUGCAGCGCACAGC | −8.4 | SELEX |
| Ovis aries | Sheep | CAGCCCCCUCAUCCAGGGGAGUGGGGUAAUA | −2.3 | SELEX |
| Capra hircus | Goat | CAGCCCCCUCAUCCAGGGGAGUGGGGUAAUA | −2.3 | SELEX |
| Camelus dromedarius | Arabian camel | CCUGAGCCGCAGCGGGAGAGCAGCGCACAGC | −8.8 | SELEX |
| Mesocricetus auratus | Golden hamster | CGGCGCCGGGUUCCAGUGAGGGCCCCGGGAA | −6.4 | SELEX |
| Physeter catodon | Sperm whale | CCUGAGCCGCGGCGGGAGAGCAGCGCACAGC | −9.2 | SELEX |
| Conserved CD63 IREs species . | Common name . | Predicted sequences . | Free energy (kcal/mol) . | IRE motif classification . |
|---|---|---|---|---|
| Homo sapiens | Human | GAGGGGGCUUGCACAGAGUUGGAGCCAGAGG | −2.3 | Typical |
| Pan paniscus | Bonobo; pygmy chimpanzee | GAGGGGGCTTGCACAGAGTTGGAGCCAGAGG | −2.3 | Typical |
| Pan troglodytes | Chimpanzee | GAGGGGGCUUGCACAGAGUUGGAGCCAGAGG | −2.3 | Typical |
| Gorilla gorilla | Western gorilla | GACGGGGCUUGCACAGAGUUGGAGCCAGAGG | −2.3 | Typical |
| Theropithecus gelada | Gelada; gelada baboon | UUUCCGGGUGGGAGGGGCCGGGAAUCG | −4.3 | SELEX |
| Bos taurus | Cattle | CCCCCCUCAUCCGGGGAGGGGGGUAAUAUAC | −3.4 | SELEX |
| Sus scrofa | Pig | CCUGAGCCGCGGCGGGAGUGCAGCGCACAGC | −8.4 | SELEX |
| Peromyscus leucopus | White-footed mouse | CCUGAGCCGCGGCGGGAGUGCAGCGCACAGC | −8.4 | SELEX |
| Ovis aries | Sheep | CAGCCCCCUCAUCCAGGGGAGUGGGGUAAUA | −2.3 | SELEX |
| Capra hircus | Goat | CAGCCCCCUCAUCCAGGGGAGUGGGGUAAUA | −2.3 | SELEX |
| Camelus dromedarius | Arabian camel | CCUGAGCCGCAGCGGGAGAGCAGCGCACAGC | −8.8 | SELEX |
| Mesocricetus auratus | Golden hamster | CGGCGCCGGGUUCCAGUGAGGGCCCCGGGAA | −6.4 | SELEX |
| Physeter catodon | Sperm whale | CCUGAGCCGCGGCGGGAGAGCAGCGCACAGC | −9.2 | SELEX |
Characters in bold indicate loop structure in the CD63 IRE; characters not shown in bold type indicate the predicted stem sequences. Typical (type I) canonical IRE motifs: 5′-CAG(U/A)GN-3′. The systematic evolution of ligands by exponential enrichment motif (SELEX) has been demonstrated to bind IRP1 and/or IRP2 in vitro.32,37