Risk of all-cause mortality according to the presence of peripheral cytopenias
| . | Unadjusted . | Adjusted* . | Adjusted† . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Anemia (<12.0 g/dL [women] or <13.0 g/dL [men]) | 1.74 (1.51-2.00) | <.001 | 1.84 (1.59-2.12) | <.001 | 1.60 (1.38-1.84) | <.001 |
| Moderate (<11.0 g/dL) | 1.71 (1.26-2.30) | <.001 | 2.76 (2.04-3.73) | <.001 | 2.41 (1.78-3.27) | <.001 |
| Severe (<10.0 g/dL) | 1.60 (0.95-2.71) | .078 | 2.61 (1.54-4.41) | <.001 | 2.41 (1.42-4.07) | .001 |
| Thrombocytopenia (<150 × 109/L) | 2.86 (2.39-3.41) | <.001 | 1.58 (1.32-1.89) | <.001 | 1.52 (1.27-1.83) | <.001 |
| Moderate (<100 × 109/L) | 5.98 (3.66-9.78) | <.001 | 4.02 (2.46-6.57) | <.001 | 3.74 (2.29-6.12) | <.001 |
| Neutropenia (<1.8 × 109/L) | 0.91 (0.76-1.09) | .301 | 0.88 (0.73-1.06) | .168 | 0.95 (0.79-1.14) | .548 |
| Moderate (<1.5 × 109/L) | 0.95 (0.69-1.32) | .763 | 0.92 (0.66-1.27) | .604 | 0.98 (0.70-1.35) | .878 |
| Severe (<0.8 × 109/L) | 1.83 (0.26-12.96) | .547 | 2.61 (0.37-18.54) | .337 | 2.81 (0.40-19.93) | .302 |
| . | Unadjusted . | Adjusted* . | Adjusted† . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Anemia (<12.0 g/dL [women] or <13.0 g/dL [men]) | 1.74 (1.51-2.00) | <.001 | 1.84 (1.59-2.12) | <.001 | 1.60 (1.38-1.84) | <.001 |
| Moderate (<11.0 g/dL) | 1.71 (1.26-2.30) | <.001 | 2.76 (2.04-3.73) | <.001 | 2.41 (1.78-3.27) | <.001 |
| Severe (<10.0 g/dL) | 1.60 (0.95-2.71) | .078 | 2.61 (1.54-4.41) | <.001 | 2.41 (1.42-4.07) | .001 |
| Thrombocytopenia (<150 × 109/L) | 2.86 (2.39-3.41) | <.001 | 1.58 (1.32-1.89) | <.001 | 1.52 (1.27-1.83) | <.001 |
| Moderate (<100 × 109/L) | 5.98 (3.66-9.78) | <.001 | 4.02 (2.46-6.57) | <.001 | 3.74 (2.29-6.12) | <.001 |
| Neutropenia (<1.8 × 109/L) | 0.91 (0.76-1.09) | .301 | 0.88 (0.73-1.06) | .168 | 0.95 (0.79-1.14) | .548 |
| Moderate (<1.5 × 109/L) | 0.95 (0.69-1.32) | .763 | 0.92 (0.66-1.27) | .604 | 0.98 (0.70-1.35) | .878 |
| Severe (<0.8 × 109/L) | 1.83 (0.26-12.96) | .547 | 2.61 (0.37-18.54) | .337 | 2.81 (0.40-19.93) | .302 |
Different cutoffs were used to evaluate the increasing severity of cytopenias, as indicated. Individuals with absence of cytopenia for the respective lineage were used as a reference.
The multivariable model included age and sex as covariates.
The multivariable model included age, sex, and the number of medications used as covariates.