Associations between clonal hematopoiesis, best overall response, and cytokine release syndrome
| Association in patients with NHL between the rate of CR and the presence of CH with a VAF ≥ 0.02 compared with all other patients (VAF < 0.02) . | |||||
|---|---|---|---|---|---|
| . | . | . | Best overall response . | ||
| . | CH status . | Total patients . | CR (%) . | No CR (%) . | P* . |
| NHL | VAF < 0.02 | 76 | 44 (57.9) | 32 (42.1) | .013 |
| VAF ≥ 0.02 | 67† | 52 (77.6) | 15 (22.4) | ||
| NHL < 60 y | VAF < 0.02 | 37 | 18 (48.6) | 19 (51.4) | .0067 |
| VAF ≥ 0.02 | 18 | 16 (88.9) | 2 (11.1) | ||
| NHL ≥ 60 y | VAF < 0.02 | 39 | 26 (66.7) | 13 (33.3) | .64 |
| VAF ≥ 0.02 | 49† | 36 (73.5) | 13 (26.5) | ||
| Association in all patients between the rate of CRS grade 2 or greater and the presence of CH with a VAF ≥ 0.02 compared with all other patients (VAF < 0.02) | |||||
| ASTCT CRS score | |||||
| CH status | Total patients | Grade < 2 (%) | Grade ≥ 2 (%) | P* | |
| NHL | VAF < 0.02 | 76 | 30 (39.5) | 46 (60.5) | .49 |
| VAF ≥ 0.02 | 68 | 23 (33.8) | 45 (66.2) | ||
| NHL < 60 y | VAF < 0.02 | 37 | 20 (54.1) | 17 (45.9) | .042 |
| VAF ≥ 0.02 | 18 | 4 (22.2) | 14 (77.8) | ||
| NHL ≥ 60 y | VAF < 0.02 | 39 | 10 (25.6) | 29 (74.4) | .26 |
| VAF ≥ 0.02 | 50 | 19 (38.0) | 31 (62.0) | ||
| Association in patients with NHL between the rate of CR and the presence of CH with a VAF ≥ 0.02 compared with all other patients (VAF < 0.02) . | |||||
|---|---|---|---|---|---|
| . | . | . | Best overall response . | ||
| . | CH status . | Total patients . | CR (%) . | No CR (%) . | P* . |
| NHL | VAF < 0.02 | 76 | 44 (57.9) | 32 (42.1) | .013 |
| VAF ≥ 0.02 | 67† | 52 (77.6) | 15 (22.4) | ||
| NHL < 60 y | VAF < 0.02 | 37 | 18 (48.6) | 19 (51.4) | .0067 |
| VAF ≥ 0.02 | 18 | 16 (88.9) | 2 (11.1) | ||
| NHL ≥ 60 y | VAF < 0.02 | 39 | 26 (66.7) | 13 (33.3) | .64 |
| VAF ≥ 0.02 | 49† | 36 (73.5) | 13 (26.5) | ||
| Association in all patients between the rate of CRS grade 2 or greater and the presence of CH with a VAF ≥ 0.02 compared with all other patients (VAF < 0.02) | |||||
| ASTCT CRS score | |||||
| CH status | Total patients | Grade < 2 (%) | Grade ≥ 2 (%) | P* | |
| NHL | VAF < 0.02 | 76 | 30 (39.5) | 46 (60.5) | .49 |
| VAF ≥ 0.02 | 68 | 23 (33.8) | 45 (66.2) | ||
| NHL < 60 y | VAF < 0.02 | 37 | 20 (54.1) | 17 (45.9) | .042 |
| VAF ≥ 0.02 | 18 | 4 (22.2) | 14 (77.8) | ||
| NHL ≥ 60 y | VAF < 0.02 | 39 | 10 (25.6) | 29 (74.4) | .26 |
| VAF ≥ 0.02 | 50 | 19 (38.0) | 31 (62.0) | ||
*P values were calculated using a Fisher’s exact test.
†One patient did not have an evaluable best overall response.