Individual aGVHD organ staging and overall aGVHD grade at time of diagnosis
| Patient no. . | GVHD onset day+ . | PANO % dose prior to GVHD onset . | Skin stage . | Gut stage . | Liver stage . | Overall grade . | GVHD treatment with systemic steroids? (> 1 mg/kg) . |
|---|---|---|---|---|---|---|---|
| 1* | 41 | 100 | 1 | 1 | 0 | II | Yes |
| 2 | 53 | 100 | 2 | 1 | 0 | II | Yes |
| 3 | 27 | 30† | 2 | 1 | 0 | II | Yes |
| 4 | 22 | 100 | 0 | 1 | 0 | II | No‡ |
| 5§ | 66 | 97 | 0 | 1 | 0 | II | No |
| 6ǁ | 18 | 100 | 0 | 1 | 0 | II | No |
| 7¶ | 38 | 45# | 0 | 3 | 0 | III | Yes |
| Patient no. . | GVHD onset day+ . | PANO % dose prior to GVHD onset . | Skin stage . | Gut stage . | Liver stage . | Overall grade . | GVHD treatment with systemic steroids? (> 1 mg/kg) . |
|---|---|---|---|---|---|---|---|
| 1* | 41 | 100 | 1 | 1 | 0 | II | Yes |
| 2 | 53 | 100 | 2 | 1 | 0 | II | Yes |
| 3 | 27 | 30† | 2 | 1 | 0 | II | Yes |
| 4 | 22 | 100 | 0 | 1 | 0 | II | No‡ |
| 5§ | 66 | 97 | 0 | 1 | 0 | II | No |
| 6ǁ | 18 | 100 | 0 | 1 | 0 | II | No |
| 7¶ | 38 | 45# | 0 | 3 | 0 | III | Yes |
Noncompliance with immunosuppression prior to GVHD.
PANO held due to rash prior to GVHD.
GVHD resolved with TAC/SIR levels adjustment.
Upper gastrointestinal symptoms suspected due to narcotic withdraw with upper gastrointestinal histology GVHD grade 1. Nausea resolved with supportive care.
Suspected delayed chemotherapy toxicity with upper gastrointestinal histology grade 1 GVHD. Symptoms resolved with supportive care.
Ruxolitinib discontinued within 30 days before HCT and GVHD resolution with steroids and ruxolitinib after HCT.
#PANO held due to AEs (confusion/prolonged QT corrected for heart rate/pneumonia).