Table 2. Multivariate Cox proportional... | American Society of Hematology

Table 2.

Multivariate Cox proportional hazards regression analyses focusing on the MRD^1st

Variables	CIR				RFS				OS
Variables	HR	Lower	Upper	P	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	0.998	0.987	1.009	.703	0.999	0.989	1.010	.889	1.012	1.000	1.024	.048
WBC counts,* ×10³/μL	1.004	1.001	1.007	.003	1.003	1.001	1.006	.007	1.003	1.000	1.006	.029
ELN risk stratification
Intermediate vs favorable	2.114	1.409	3.172	<.001	2.156	1.475	3.151	<.001	2.534	1.641	3.913	<.001
Adverse vs favorable	2.583	1.621	4.116	<.001	2.628	1.704	4.052	<.001	2.816	1.738	4.565	<.001
Number of induction chemotherapy cycles†	1.597	1.058	2.412	.026	1.560	1.068	2.279	.021	1.501	1.004	2.244	.048
HSCT at CR1‡	0.206	0.118	0.360	<.001	0.293	0.183	0.467	<.001	0.568	0.353	0.912	.019
MRD^1st§	1.739	1.223	2.473	.002	1.656	1.196	2.294	.002	1.545	1.068	2.233	.021

Variables	CIR				RFS				OS
Variables	HR	Lower	Upper	P	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	0.998	0.987	1.009	.703	0.999	0.989	1.010	.889	1.012	1.000	1.024	.048
WBC counts,* ×10³/μL	1.004	1.001	1.007	.003	1.003	1.001	1.006	.007	1.003	1.000	1.006	.029
ELN risk stratification
Intermediate vs favorable	2.114	1.409	3.172	<.001	2.156	1.475	3.151	<.001	2.534	1.641	3.913	<.001
Adverse vs favorable	2.583	1.621	4.116	<.001	2.628	1.704	4.052	<.001	2.816	1.738	4.565	<.001
Number of induction chemotherapy cycles†	1.597	1.058	2.412	.026	1.560	1.068	2.279	.021	1.501	1.004	2.244	.048
HSCT at CR1‡	0.206	0.118	0.360	<.001	0.293	0.183	0.467	<.001	0.568	0.353	0.912	.019
MRD^1st§	1.739	1.223	2.473	.002	1.656	1.196	2.294	.002	1.545	1.068	2.233	.021

Continuous variables.

Two cycles vs 1 cycle.

HSCT at CR1 vs HSCT at other disease status or without HSCT.

MRD positivity vs negativity at the first time point. The MRD positivity and negativity are evaluated after excluding DTA mutations.