Diagnostic criteria for MDS entities
| Name . | Dysplastic lineages . | Cytopenias . | RS (%)* . | BM and PB blasts (%) . | Cytogenetics† . |
|---|---|---|---|---|---|
| MDS-SLD | 1 | 1 or 2 | <15/<5‡ | BM <5, PB <1, no Auer rods | Any, unless fulfills all criteria for MDS with isolated del(5q) |
| MDS-MLD | 2 or 3 | 1-3 | <15/<5‡ | BM <5, PB <1, no Auer rods | Any, unless fulfills all criteria for MDS with isolated del(5q) |
| MDS-RS | |||||
| MDS-RS-SLD | 1 | 1 or 2 | ≥15/≥5‡ | BM < 5, PB <1, no Auer rods | Any, unless fulfills all criteria for MDS with isolated del(5q) |
| MDS-RS-MLD | 2 or 3 | 1-3 | ≥15/≥5‡ | BM <5, PB <1, no Auer rods | Any, unless fulfills all criteria for MDS with isolated del(5q) |
| MDS with isolated del(5q) | 1-3 | 1-2 | None or any | BM <5, PB <1, no Auer rods | Del(5q) alone or with 1 additional abnormality except −7 or del(7q) |
| MDS-EB | |||||
| MDS-EB-1 | 0-3 | 1-3 | None or any | BM 5-9 or PB 2-4, no Auer rods | Any |
| MDS-EB-2 | 0-3 | 1-3 | None or any | BM 10-19 or PB 5-19 or Auer rods | Any |
| MDS-U | |||||
| 1% blood blasts | 1-3 | 1-3 | None or any | BM <5, PB = 1,§ no Auer rods | Any |
| SLD and pancytopenia | 1 | 3 | None or any | BM <5, PB <1, no Auer rods | Any |
| Defining cytogenetic abnormality | 0 | 1-3 | <15|| | BM <5, PB <1, no Auer rods | MDS-defining abnormality |
| Refractory cytopenia of childhood | 1-3 | 1-3 | None | BM <5, PB <2 | Any |
| Name . | Dysplastic lineages . | Cytopenias . | RS (%)* . | BM and PB blasts (%) . | Cytogenetics† . |
|---|---|---|---|---|---|
| MDS-SLD | 1 | 1 or 2 | <15/<5‡ | BM <5, PB <1, no Auer rods | Any, unless fulfills all criteria for MDS with isolated del(5q) |
| MDS-MLD | 2 or 3 | 1-3 | <15/<5‡ | BM <5, PB <1, no Auer rods | Any, unless fulfills all criteria for MDS with isolated del(5q) |
| MDS-RS | |||||
| MDS-RS-SLD | 1 | 1 or 2 | ≥15/≥5‡ | BM < 5, PB <1, no Auer rods | Any, unless fulfills all criteria for MDS with isolated del(5q) |
| MDS-RS-MLD | 2 or 3 | 1-3 | ≥15/≥5‡ | BM <5, PB <1, no Auer rods | Any, unless fulfills all criteria for MDS with isolated del(5q) |
| MDS with isolated del(5q) | 1-3 | 1-2 | None or any | BM <5, PB <1, no Auer rods | Del(5q) alone or with 1 additional abnormality except −7 or del(7q) |
| MDS-EB | |||||
| MDS-EB-1 | 0-3 | 1-3 | None or any | BM 5-9 or PB 2-4, no Auer rods | Any |
| MDS-EB-2 | 0-3 | 1-3 | None or any | BM 10-19 or PB 5-19 or Auer rods | Any |
| MDS-U | |||||
| 1% blood blasts | 1-3 | 1-3 | None or any | BM <5, PB = 1,§ no Auer rods | Any |
| SLD and pancytopenia | 1 | 3 | None or any | BM <5, PB <1, no Auer rods | Any |
| Defining cytogenetic abnormality | 0 | 1-3 | <15|| | BM <5, PB <1, no Auer rods | MDS-defining abnormality |
| Refractory cytopenia of childhood | 1-3 | 1-3 | None | BM <5, PB <2 | Any |
BM, bone marrow; MDS-EB, MDS with excess blasts; MDS-U, MDS, unclassifiable; PB, peripheral blood.
RS as percentage of marrow erythroid elements.
Cytogenetics by conventional karyotype analysis.
If SF3B1 mutation is present.
One percent PB blasts must be recorded on ≥2 separate occasions.
Cases with ≥15% RS by definition have significant erythroid dysplasia and are classified as MDS-RS-SLD.