Patterns of differentiation response with IDHi/7+3 therapy
| Patient . | IDH mutation . | IDHi received . | Dx BM, cellularity (blast %) . | D14 BM, cellularity (blast %) . | Diff. morphology . | Diff. seen by flow cytometry . | Time when Diff. seen . | Time to CR/CRi/p, d . | Induction cycles to achieve CR/CRi/p . |
|---|---|---|---|---|---|---|---|---|---|
| D14D-1 | IDH1 R132H | AG-120 | 95 (75) | 10 (12.5) | Granulocytic | Y | D14 | 28 | 1 |
| D14D-2 | IDH1 R132L | AG-120 | 70 (71.5) | 10 (50) | Monocytic | Y | D14 | 36 | 1 |
| D14D-3 | IDH1 R132C | AG-120 | 40 (40) | 10 (60) | Monocytic | ND | D21 | 58 | 2 |
| D14D-4 | IDH2 R172K | AG-221 | 60 (90) | 20 (5) | Monocytic | ND | D14 | 37 | 1 |
| D14D-5 | IDH2 R140Q | AG-221 | 60 (90) | 20 (10) | Monocytic | ND | D14 | 43 | 1 |
| D14D-6 | IDH2 R172K | AG-221 | 60 (70) | 20 (30) | Monocytic | ND | D14 | 52 | 2 |
| D14D-7 | IDH2 R172K | AG-221 | 70 (55) | ND (34) | Myelomonocytic | Y | D14 | 32 | 1 |
| D14D-8 | IDH2-R140Q/IDH1 R132H | AG-221 | 80 (90) | 20 (45) | Monocytic | ND | D14 | 49 | 2 |
| D14D-9 | IDH2 R140Q | AG-221 | 95 (81) | 20 (66.5) | Monocytic | Y | D14 | 35 | 1 |
| D14D-10 | IDH2 R172K | AG-221 | 60 (21) | 20 (80) | Granulocytic | Y | D21 | 40 | 1 |
| Patient . | IDH mutation . | IDHi received . | Dx BM, cellularity (blast %) . | D14 BM, cellularity (blast %) . | Diff. morphology . | Diff. seen by flow cytometry . | Time when Diff. seen . | Time to CR/CRi/p, d . | Induction cycles to achieve CR/CRi/p . |
|---|---|---|---|---|---|---|---|---|---|
| D14D-1 | IDH1 R132H | AG-120 | 95 (75) | 10 (12.5) | Granulocytic | Y | D14 | 28 | 1 |
| D14D-2 | IDH1 R132L | AG-120 | 70 (71.5) | 10 (50) | Monocytic | Y | D14 | 36 | 1 |
| D14D-3 | IDH1 R132C | AG-120 | 40 (40) | 10 (60) | Monocytic | ND | D21 | 58 | 2 |
| D14D-4 | IDH2 R172K | AG-221 | 60 (90) | 20 (5) | Monocytic | ND | D14 | 37 | 1 |
| D14D-5 | IDH2 R140Q | AG-221 | 60 (90) | 20 (10) | Monocytic | ND | D14 | 43 | 1 |
| D14D-6 | IDH2 R172K | AG-221 | 60 (70) | 20 (30) | Monocytic | ND | D14 | 52 | 2 |
| D14D-7 | IDH2 R172K | AG-221 | 70 (55) | ND (34) | Myelomonocytic | Y | D14 | 32 | 1 |
| D14D-8 | IDH2-R140Q/IDH1 R132H | AG-221 | 80 (90) | 20 (45) | Monocytic | ND | D14 | 49 | 2 |
| D14D-9 | IDH2 R140Q | AG-221 | 95 (81) | 20 (66.5) | Monocytic | Y | D14 | 35 | 1 |
| D14D-10 | IDH2 R172K | AG-221 | 60 (21) | 20 (80) | Granulocytic | Y | D21 | 40 | 1 |
CR, complete response; CR/CRi/p, CR/CR with incomplete hematologic recovery/CR with incomplete platelet recovery; D14, day 14; D21, day 21; Diff., differentiation; ND, no data; Y, yes.