SCID-X1 dogs treated with in vivo–injected foamy virus vector
| Animal . | Age at injection . | Titer (I.U./mL) . | VCM volume (mL) . | Final dose (I.U.) . | Survival (days) . |
|---|---|---|---|---|---|
| X348 | 13 d.o. | 1.4 × 108 | 1.4 (×2) | 4.0 × 108 | 139 |
| X349 | 13 d.o. | 1.4 × 108 | 1.4 (×2) | 4.0 × 108 | 306 |
| R2152 | 12 d.o. | 3 × 108 | 1.4 (×2) | 8.4 × 108 | 101 |
| R2202 | 1 d.o. | 3 × 108 | 0.7 (×2) | 4.2 × 108 | 330 |
| R2203 | 1 d.o. | 3 × 108 | 0.7 (×2) | 4.2 × 108 | 119 |
| Animal . | Age at injection . | Titer (I.U./mL) . | VCM volume (mL) . | Final dose (I.U.) . | Survival (days) . |
|---|---|---|---|---|---|
| X348 | 13 d.o. | 1.4 × 108 | 1.4 (×2) | 4.0 × 108 | 139 |
| X349 | 13 d.o. | 1.4 × 108 | 1.4 (×2) | 4.0 × 108 | 306 |
| R2152 | 12 d.o. | 3 × 108 | 1.4 (×2) | 8.4 × 108 | 101 |
| R2202 | 1 d.o. | 3 × 108 | 0.7 (×2) | 4.2 × 108 | 330 |
| R2203 | 1 d.o. | 3 × 108 | 0.7 (×2) | 4.2 × 108 | 119 |
Virus was delivered in 2 fractionated doses, 4 hours apart, at the day of life indicated for each dog. The VCM volume is volume per injection, and the total volume received is multiplied by 2 for fractionated injections.
d.o., days old; I.U., infectious units; VCM, vector-conditioned medium.