Predictors of major bleeding
| Description . | χ2 . | P . | HR (95% CI)* . |
|---|---|---|---|
| Age,y | 82.57 | <.0001 | 1.23 (1.18-1.29) |
| Comparisons of antithrombotic strategies | 62.25 | <.0001 | |
| AP vs NOAC | 0.71 (0.52-0.96) | ||
| NOAC + AP vs NOAC | 1.78 (1.26-2.51) | ||
| VKA vs NOAC | 1.38 (1.09-1.75) | ||
| VKA + AP vs VKA | 1.53 (1.20-1.95) | ||
| Moderate or severe CKD | 28.54 | <.0001 | 1.72 (1.41-2.10) |
| History of bleeding | 27.22 | <.0001 | 2.38 (1.72-3.30) |
| Pulse (per 5 bpm) | 9.17 | .003 | 1.02 (1.01-1.04) |
| Diabetes | 6.43 | .011 | 1.26 (1.05-1.50) |
| Asian vs not Asian | 5.66 | .018 | 0.77 (0.62-0.96) |
| Height per 5 (cm) | 5.27 | .022 | 0.95 (0.91-0.99) |
| Carotid occlusive disease | 3.88 | .049 | 1.41 (1.00-1.98) |
| Vascular disease | 3.49 | .061 | 1.19 (0.99-1.43) |
| Description . | χ2 . | P . | HR (95% CI)* . |
|---|---|---|---|
| Age,y | 82.57 | <.0001 | 1.23 (1.18-1.29) |
| Comparisons of antithrombotic strategies | 62.25 | <.0001 | |
| AP vs NOAC | 0.71 (0.52-0.96) | ||
| NOAC + AP vs NOAC | 1.78 (1.26-2.51) | ||
| VKA vs NOAC | 1.38 (1.09-1.75) | ||
| VKA + AP vs VKA | 1.53 (1.20-1.95) | ||
| Moderate or severe CKD | 28.54 | <.0001 | 1.72 (1.41-2.10) |
| History of bleeding | 27.22 | <.0001 | 2.38 (1.72-3.30) |
| Pulse (per 5 bpm) | 9.17 | .003 | 1.02 (1.01-1.04) |
| Diabetes | 6.43 | .011 | 1.26 (1.05-1.50) |
| Asian vs not Asian | 5.66 | .018 | 0.77 (0.62-0.96) |
| Height per 5 (cm) | 5.27 | .022 | 0.95 (0.91-0.99) |
| Carotid occlusive disease | 3.88 | .049 | 1.41 (1.00-1.98) |
| Vascular disease | 3.49 | .061 | 1.19 (0.99-1.43) |
CI, confidence interval.
Adjusted for country of enrolment, cohort of enrolment, sex, age, race/ethnicity, type of AF, care setting, specialty, heart failure, acute coronary syndromes, vascular disease, carotid occlusive disease, prior stroke/TIA/SE, prior bleeding, VTE, hypertension, hypercholesterolemia, diabetes, cirrhosis, moderate to severe CKD, dementia, hyperthyroidism, hypothyroidism, current smoking, heavy alcohol consumption, BMI, heart rate, baseline systolic and diastolic blood pressure, baseline AP use.