Evolution of TTP treatment
| The past (1924 to 1975): No effective treatment |
| 10% survival |
| The beginning (1976 to 1990): Effective treatment |
| Whole-blood exchange transfusion (1976) |
| Plasma infusion (1977) |
| The present (1991 to 2020): Increasingly effective treatment |
| Plasma exchange (1991, 78% survival) |
| Corticosteroids (1991) |
| Plasma exchange, corticosteroids, rituximab (2002) |
| Plasma exchange, corticosteroids, rituximab, caplacizumab (2020, 99% survival)* |
| The future? (2021-): Simpler, safer treatment |
| Caplacizumab, rituximab |
| The past (1924 to 1975): No effective treatment |
| 10% survival |
| The beginning (1976 to 1990): Effective treatment |
| Whole-blood exchange transfusion (1976) |
| Plasma infusion (1977) |
| The present (1991 to 2020): Increasingly effective treatment |
| Plasma exchange (1991, 78% survival) |
| Corticosteroids (1991) |
| Plasma exchange, corticosteroids, rituximab (2002) |
| Plasma exchange, corticosteroids, rituximab, caplacizumab (2020, 99% survival)* |
| The future? (2021-): Simpler, safer treatment |
| Caplacizumab, rituximab |
Coppo et al.