Patient demographics, donor details, and transplant conditioning for allo-HSCT patients whose biopsies were included in study
| Patient UPN . | Age, y . | Diagnosis . | Conditioning . | Donor . | HLA match . |
|---|---|---|---|---|---|
| 1 | 32 | AML | RIC (Flu/Mel*) | Unrelated | M/m |
| 2 | 65 | CLL | RIC (Flu/Bu) | Unrelated | Matched |
| 3 | 36 | CML | RIC (Flu/Mel*) | Related | M/m |
| 4 | 50 | AML | RIC (Flu/Mel*) | Unrelated | M/m |
| 5 | 51 | Myeloma | RIC (Flu/Cy) | Related | Matched |
| 6 | 62 | FL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 7 | 62 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 8 | 47 | Myeloma | RIC (Flu/Cy) | Unrelated | Matched |
| 9 | 51 | ALL | RIC (Flu/Cy) | Unrelated | Matched |
| 10 | 53 | NHL | RIC (Flu/Cy) | Unrelated | Matched |
| 11 | 32 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 12 | 51 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 13 | 44 | AML | RIC (Flu/Cy) | Related | Matched |
| 14 | 31 | ALL | MA (Cy/TBI) | Unrelated | Matched |
| 15 | 62 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 16 | 58 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 17 | 46 | MF | RIC (Flu/Cy) | Related | Matched |
| 18 | 59 | CLL (LPD) | RIC (Flu/Bu) | Unrelated | Matched |
| 19 | 41 | FL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 20 | 35 | CML | MA (Bu/Cy) | Related | Matched |
| 21 | 22 | ALL | MA (Bu/Cy) | Unrelated | Matched |
| 22 | 53 | AML | RIC (Flu/Cy) | Related | Matched |
| 23 | 57 | FL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 24 | 30 | ALL | MA (Cy/TBI) | Unrelated | Matched |
| 25 | 63 | AML | RIC (Flu/Cy) | Related | Matched |
| 26 | 66 | CLL (LPD) | RIC (Flu/Bu) | Unrelated | Matched |
| 27 | 64 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 28 | 42 | HD (LPD) | RIC (BEAM)* | Unrelated | Matched |
| 29 | 59 | AML | RIC (Flu/Cy) | Related | Matched |
| 30 | 51 | MDS | RIC (Flu/Cy) | Related | Matched |
| 31 | 43 | ALL | RIC (Flu/Cy) | Related | Matched |
| 32 | 41 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 33 | 33 | AA | RIC (Flu/Cy/TBI*) | Unrelated | Matched |
| 34 | 38 | ALL | RIC (Flu/Cy) | Related | Matched |
| 35 | 39 | CLL (LPD) | RIC (Flu/Mel*) | Unrelated | M/m |
| 36 | 20 | AML | RIC (Flu/Cy) | Unrelated | Matched |
| 37 | 43 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 38 | 38 | ALL | RIC (Flu/Cy) | Unrelated | Matched |
| 39 | 56 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 40 | 53 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 41 | 41 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 42 | 51 | AML | RIC (Flu/Cy) | Related | Matched |
| 43 | 60 | CLL (LPD) | RIC (Flu/Bu) | Unrelated | Matched |
| 44 | 64 | AML | RIC (Flu/Cy) | Related | Matched |
| 45 | 58 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 46 | 47 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 47 | 43 | FL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 48 | 65 | AML | RIC (Flu/Cy) | Unrelated | Matched |
| 49 | 64 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 50 | 55 | CLL (LPD) | RIC (Flu/Bu) | Related | Matched |
| 51 | 48 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 52 | 57 | AML | RIC (Flu/Cy) | Unrelated | Matched |
| 53 | 51 | DLBCL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 54 | 52 | AML | RIC (Flu/Cy) | Related | Matched |
| Patient UPN . | Age, y . | Diagnosis . | Conditioning . | Donor . | HLA match . |
|---|---|---|---|---|---|
| 1 | 32 | AML | RIC (Flu/Mel*) | Unrelated | M/m |
| 2 | 65 | CLL | RIC (Flu/Bu) | Unrelated | Matched |
| 3 | 36 | CML | RIC (Flu/Mel*) | Related | M/m |
| 4 | 50 | AML | RIC (Flu/Mel*) | Unrelated | M/m |
| 5 | 51 | Myeloma | RIC (Flu/Cy) | Related | Matched |
| 6 | 62 | FL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 7 | 62 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 8 | 47 | Myeloma | RIC (Flu/Cy) | Unrelated | Matched |
| 9 | 51 | ALL | RIC (Flu/Cy) | Unrelated | Matched |
| 10 | 53 | NHL | RIC (Flu/Cy) | Unrelated | Matched |
| 11 | 32 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 12 | 51 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 13 | 44 | AML | RIC (Flu/Cy) | Related | Matched |
| 14 | 31 | ALL | MA (Cy/TBI) | Unrelated | Matched |
| 15 | 62 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 16 | 58 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 17 | 46 | MF | RIC (Flu/Cy) | Related | Matched |
| 18 | 59 | CLL (LPD) | RIC (Flu/Bu) | Unrelated | Matched |
| 19 | 41 | FL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 20 | 35 | CML | MA (Bu/Cy) | Related | Matched |
| 21 | 22 | ALL | MA (Bu/Cy) | Unrelated | Matched |
| 22 | 53 | AML | RIC (Flu/Cy) | Related | Matched |
| 23 | 57 | FL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 24 | 30 | ALL | MA (Cy/TBI) | Unrelated | Matched |
| 25 | 63 | AML | RIC (Flu/Cy) | Related | Matched |
| 26 | 66 | CLL (LPD) | RIC (Flu/Bu) | Unrelated | Matched |
| 27 | 64 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 28 | 42 | HD (LPD) | RIC (BEAM)* | Unrelated | Matched |
| 29 | 59 | AML | RIC (Flu/Cy) | Related | Matched |
| 30 | 51 | MDS | RIC (Flu/Cy) | Related | Matched |
| 31 | 43 | ALL | RIC (Flu/Cy) | Related | Matched |
| 32 | 41 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 33 | 33 | AA | RIC (Flu/Cy/TBI*) | Unrelated | Matched |
| 34 | 38 | ALL | RIC (Flu/Cy) | Related | Matched |
| 35 | 39 | CLL (LPD) | RIC (Flu/Mel*) | Unrelated | M/m |
| 36 | 20 | AML | RIC (Flu/Cy) | Unrelated | Matched |
| 37 | 43 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 38 | 38 | ALL | RIC (Flu/Cy) | Unrelated | Matched |
| 39 | 56 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 40 | 53 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 41 | 41 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 42 | 51 | AML | RIC (Flu/Cy) | Related | Matched |
| 43 | 60 | CLL (LPD) | RIC (Flu/Bu) | Unrelated | Matched |
| 44 | 64 | AML | RIC (Flu/Cy) | Related | Matched |
| 45 | 58 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 46 | 47 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 47 | 43 | FL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 48 | 65 | AML | RIC (Flu/Cy) | Unrelated | Matched |
| 49 | 64 | MCL (LPD) | RIC (Flu/Cy) | Related | Matched |
| 50 | 55 | CLL (LPD) | RIC (Flu/Bu) | Related | Matched |
| 51 | 48 | MDS | RIC (Flu/Cy) | Unrelated | Matched |
| 52 | 57 | AML | RIC (Flu/Cy) | Unrelated | Matched |
| 53 | 51 | DLBCL (LPD) | RIC (Flu/Cy) | Unrelated | Matched |
| 54 | 52 | AML | RIC (Flu/Cy) | Related | Matched |
Matched, HLA-matched (at A, B, C and DR); M/m, HLA-mismatched at a single HLA-A or -C locus.
AA, aplastic anemia; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; BEAM, carmustine, etoposide, cytarabine, and melphalan; Bu, busulphan; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia; Cy, cyclophosphamide; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; Flu, fludarabine; LPD, lymphoproliferative disorder; MA, myeloablative; MCL, mantle cell lymphoma; MDS, myelodysplastic syndrome; Mel, melphalan; MF, myelofibrosis; M/m, mismatched (single antigen); MPD, myeloproliferative disorder; NHL, non-Hodgkin lymphoma; RIC, reduced-intensity conditioning; TBI, total body irradiation; UPN, unique patient number.
In vivo alemtuzumab.