Comparison of grade 3 to 4 adverse events during the induction course
| Adverse event . | CALGB 10403 (N = 289) . | COG AALL0232 (N = 158) . | P* . |
|---|---|---|---|
| Hyperglycemia | 31.1% (90) | 22.8% (36) | .06 |
| Aspartate aminotransferase | 12.8% (37) | 5.7% (9) | .02 |
| Alanine aminotransferase | 28.7% (83) | 17.7% (28) | .01 |
| Hyperbilirubinemia | 19.0% (55) | 7.0% (11) | <.001 |
| Anaphylaxis | 1.4% (4) | 0.6% (1) | .66 |
| Pancreatitis | 2.8% (8) | 1.3% (2) | .51 |
| Thrombosis | 5.2% (15) | 1.9% (3) | .13 |
| Febrile neutropenia* | 23.9% (69) | 5.7% (9) | <.001 |
| Infection | 24.6% (71) | 22.8% (36) | .67 |
| Adverse event . | CALGB 10403 (N = 289) . | COG AALL0232 (N = 158) . | P* . |
|---|---|---|---|
| Hyperglycemia | 31.1% (90) | 22.8% (36) | .06 |
| Aspartate aminotransferase | 12.8% (37) | 5.7% (9) | .02 |
| Alanine aminotransferase | 28.7% (83) | 17.7% (28) | .01 |
| Hyperbilirubinemia | 19.0% (55) | 7.0% (11) | <.001 |
| Anaphylaxis | 1.4% (4) | 0.6% (1) | .66 |
| Pancreatitis | 2.8% (8) | 1.3% (2) | .51 |
| Thrombosis | 5.2% (15) | 1.9% (3) | .13 |
| Febrile neutropenia* | 23.9% (69) | 5.7% (9) | <.001 |
| Infection | 24.6% (71) | 22.8% (36) | .67 |
Number of patients is given in parentheses.
χ2 or Fisher’s exact test.