Demographic and laboratory data of all patients with MBDs and healthy controls
| . | All patients, n (%) or median [IQR] (N = 620) . | Controls, n (%) or median [IQR] (n = 100) . | P . |
|---|---|---|---|
| Age, y | 40 [28-53] | 38 [28-50] | .386 |
| Female | 505 (81.5) | 81 (81.0) | .914 |
| Blood group O | 314 (51.1) | 31 (31.0) | <.001 |
| Positive family history | 232 (37.4) | na | na |
| BMI, kg/m2 | 23.1 [21.0-26.2] | 22.2 [20.7-25.2] | .044 |
| Hemoglobin, g/dL | 13.6 [12.8-14.4] | 13.7 [13-14.5] | .196 |
| Platelet count, ×109/L | 225 [209-284] | 264 [224-294] | .095 |
| aPTT-STA, s | 35.9 [33.7-38.9] | 35.1 [33.3-36.4] | <.001 |
| Prothrombin time, % | 95 [88-104] | 100 [92-109] | <.001 |
| Fibrinogen, mg/dL | 306.5 [266.0-353.8] | 290.0 [244.0-340.3] | .070 |
| FVIII, % | 120.0 [96.0-153.0] | 131.0 [105.5-157.8] | .058 |
| FIX, % | 104.0 [89.0-120.0] | 100.0 [89.8-114.0] | .213 |
| VWF:Ag, % | 94.0 [72.0-117.0] | 104.0 [93.0-135.0] | <.001 |
| VWF:RCo, % | 78.0 [63.0-116.5] | 93.0 [71.0-127.3] | .002 |
| Vicenza Bleeding Score | 5 [4-8] | 0 [0-0] | <.001 |
| ISTH BAT* | 6 [4-9] | 0 [0-0] | <.001 |
| . | All patients, n (%) or median [IQR] (N = 620) . | Controls, n (%) or median [IQR] (n = 100) . | P . |
|---|---|---|---|
| Age, y | 40 [28-53] | 38 [28-50] | .386 |
| Female | 505 (81.5) | 81 (81.0) | .914 |
| Blood group O | 314 (51.1) | 31 (31.0) | <.001 |
| Positive family history | 232 (37.4) | na | na |
| BMI, kg/m2 | 23.1 [21.0-26.2] | 22.2 [20.7-25.2] | .044 |
| Hemoglobin, g/dL | 13.6 [12.8-14.4] | 13.7 [13-14.5] | .196 |
| Platelet count, ×109/L | 225 [209-284] | 264 [224-294] | .095 |
| aPTT-STA, s | 35.9 [33.7-38.9] | 35.1 [33.3-36.4] | <.001 |
| Prothrombin time, % | 95 [88-104] | 100 [92-109] | <.001 |
| Fibrinogen, mg/dL | 306.5 [266.0-353.8] | 290.0 [244.0-340.3] | .070 |
| FVIII, % | 120.0 [96.0-153.0] | 131.0 [105.5-157.8] | .058 |
| FIX, % | 104.0 [89.0-120.0] | 100.0 [89.8-114.0] | .213 |
| VWF:Ag, % | 94.0 [72.0-117.0] | 104.0 [93.0-135.0] | <.001 |
| VWF:RCo, % | 78.0 [63.0-116.5] | 93.0 [71.0-127.3] | .002 |
| Vicenza Bleeding Score | 5 [4-8] | 0 [0-0] | <.001 |
| ISTH BAT* | 6 [4-9] | 0 [0-0] | <.001 |
FIX, factor IX activity; FVIII, factor VIII activity; ISTH BAT, International Society on Thrombosis and Haemostasis Bleeding Assessment Tool; na, not available.
ISTH Bleeding Score available for 359 patients (57.9%).