Derivation of the HIGH-2-LOW VTE RAM
| Proposed risk factor . | OR (95% CI) . | Weight* . | Score distribution . | Risk stratification . |
|---|---|---|---|---|
| History of CR-DVT (n = 81) | 2.10 (0.80-5.53) | 1 | ||
| Inpatient admission (30 d) (n = 280) | 2.02 (1.06-3.86) | 1 | 0 = 921 | |
| GVHD grade 3 to 4 (30 d) (n = 127) | 1.74 (0.77-3.91) | 1 | 1 = 507 | 0 = low risk (n = 921) |
| History of PE or LE-DVT (n = 52) | 2.54 (0.92-7.05) | 2 | 2 = 201 | 1 = intermediate (n = 507) |
| Lymphoma diagnosis (n = 209) | 3.47 (1.89-6.38) | 1 | 3 = 60 | 2+ = high risk (n = 275) |
| Obesity (BMI ≥35 kg/m2) (n = 61) | 2.54 (1.26-5.13) | 1 | 4 = 10 | |
| WBC ≥11 × 109/L (30 d) (n = 202) | 1.95 (0.99-3.84) | 1 | 5 = 4 |
| Proposed risk factor . | OR (95% CI) . | Weight* . | Score distribution . | Risk stratification . |
|---|---|---|---|---|
| History of CR-DVT (n = 81) | 2.10 (0.80-5.53) | 1 | ||
| Inpatient admission (30 d) (n = 280) | 2.02 (1.06-3.86) | 1 | 0 = 921 | |
| GVHD grade 3 to 4 (30 d) (n = 127) | 1.74 (0.77-3.91) | 1 | 1 = 507 | 0 = low risk (n = 921) |
| History of PE or LE-DVT (n = 52) | 2.54 (0.92-7.05) | 2 | 2 = 201 | 1 = intermediate (n = 507) |
| Lymphoma diagnosis (n = 209) | 3.47 (1.89-6.38) | 1 | 3 = 60 | 2+ = high risk (n = 275) |
| Obesity (BMI ≥35 kg/m2) (n = 61) | 2.54 (1.26-5.13) | 1 | 4 = 10 | |
| WBC ≥11 × 109/L (30 d) (n = 202) | 1.95 (0.99-3.84) | 1 | 5 = 4 |
The sum of the covariate weights was used to stratify risk of VTE: low risk = 0, intermediate risk = 1, and high risk ≥2. Baseline risk predictors were assessed at 30 d posttransplant, and binary VTE outcomes were assessed at 100 d posttransplant.
WBC, white blood cell count.