Table 4.

Associations between each laboratory or clinical marker and TRV as a continuous variable in each group and the entire cohort

Group 1Group 2Group 3Group 4All
EstSESection 1.01 PEstSESection 1.02 PEstSESection 1.03 PEstSESection 1.04 PEstSESection 1.05 P
Hb* −0.06 0.03 .04 −0.06 0.03 .05 0.01 0.02 .54 −0.05 0.04 .17 −0.03 0.01 .02 
ARC* 0.76 0.33 .02 0.15 0.36 .67 0.15 0.32 .63 −0.08 0.32 .81 0.34 0.16 .03 
LDH 0.08 0.03 .02 0.02 0.04 .57 0.03 0.03 .25 0.05 0.04 .25 0.05 0.02 <.01 
Bilirubin 0.08 0.10 .43 0.10 0.13 .46 0.09 0.09 .31 0.16 0.12 .17 0.12 0.05 .02 
WBC 0.20 0.12 .09 −0.17 0.15 .25 −0.10 0.10 .34 −0.18 0.14 .23 0.02 0.06 .73 
Platelet 0.02 0.04 .61 0.03 0.04 .48 0.01 0.02 .77 0.04 0.04 .40 0.02 0.02 .19 
VWF 0.02 0.05 .63 −0.02 0.06 .70 0.04 0.05 .40 0.04 0.07 .62 0.03 0.03 .29 
FVIII −0.01 0.05 .81 0.01 0.06 .82 0 0.05 .95 0.01 0.07 .83 0.01 0.03 .73 
CRP* 0.01 0.05 .87 −0.06 0.03 .07 −0.01 0.05 .81 0.04 0.21 .84 −0.02 0.02 .37 
Ferritin −0.01 0.02 .70 −0.06 0.03 .06 −0.01 0.01 .33 0 0.01 .66 −0.01 0.01 .32 
E-selectin 0.05 0.04 .25 0.01 0.06 .92 0.08 0.04 .06 0.12 0.08 .15 0.06 0.02 <.01 
EGF −0.02 0.02 .48 0.01 0.03 .77 0 0.02 .84 −0.01 0.03 .82 0 0.01 .83 
IL7 0 0.07 .94 0.21 0.09 .04 −0.05 0.04 .15 −0.01 0.06 .90 −0.01 0.03 .64 
sVCAM 0.08 0.04 .06 0.05 0.04 .25 −0.01 0.03 .69 0.02 0.04 .68 0.03 0.02 .15 
MIP-1α 0.01 0.01 .35 0 0.01 .85 −0.01 0.01 .49 0.01 0.01 .59 0 0 .83 
MIP-1β 0.07 0.04 .07 0.06 0.06 .36 0.03 0.04 .36 0.13 0.05 .02 0.06 0.02 <.01 
sCD40L 0 0.01 .70 0 0.01 .92 0 0.01 .89 0 0.01 .81 0 0.01 .94 
IFN-α2 0.03 0.02 .22 0.10 0.03 <.01 −0.01 0.02 .74 0.05 0.03 .09 0.02 0.01 .04 
IL-4 0.05 0.03 .13 0.08 0.04 .06 0 0.03 .88 0.04 0.03 .21 0.03 0.02 .05 
NT-proBNP 0.04 0.02 .05 0.03 0.03 .37 0 0.02 .88 −0.05 0.03 .14 0.01 0.01 .31 
UPCR 0.02 0.03 .60 0.04 0.05 .41 0.04 0.02 .08 0.04 0.04 .32 0.04 0.02 .01 
ACS† 0.01 0.08 .87 −0.08 0.08 .27 0.01 0.04 .84 −0.06 0.09 .53 0.01 0.03 .86 
VOC† 0.00 0.02 .86 0.02 0.01 .04 0.00 0.01 .84 −0.01 0.03 .65 0.00 0.01 .55 
ACS + VOC† 0.00 0.02 .89 0.02 0.01 .06 0.00 0.01 .89 −0.01 0.02 .56 0.00 0.01 .55 
Group 1Group 2Group 3Group 4All
EstSESection 1.01 PEstSESection 1.02 PEstSESection 1.03 PEstSESection 1.04 PEstSESection 1.05 P
Hb* −0.06 0.03 .04 −0.06 0.03 .05 0.01 0.02 .54 −0.05 0.04 .17 −0.03 0.01 .02 
ARC* 0.76 0.33 .02 0.15 0.36 .67 0.15 0.32 .63 −0.08 0.32 .81 0.34 0.16 .03 
LDH 0.08 0.03 .02 0.02 0.04 .57 0.03 0.03 .25 0.05 0.04 .25 0.05 0.02 <.01 
Bilirubin 0.08 0.10 .43 0.10 0.13 .46 0.09 0.09 .31 0.16 0.12 .17 0.12 0.05 .02 
WBC 0.20 0.12 .09 −0.17 0.15 .25 −0.10 0.10 .34 −0.18 0.14 .23 0.02 0.06 .73 
Platelet 0.02 0.04 .61 0.03 0.04 .48 0.01 0.02 .77 0.04 0.04 .40 0.02 0.02 .19 
VWF 0.02 0.05 .63 −0.02 0.06 .70 0.04 0.05 .40 0.04 0.07 .62 0.03 0.03 .29 
FVIII −0.01 0.05 .81 0.01 0.06 .82 0 0.05 .95 0.01 0.07 .83 0.01 0.03 .73 
CRP* 0.01 0.05 .87 −0.06 0.03 .07 −0.01 0.05 .81 0.04 0.21 .84 −0.02 0.02 .37 
Ferritin −0.01 0.02 .70 −0.06 0.03 .06 −0.01 0.01 .33 0 0.01 .66 −0.01 0.01 .32 
E-selectin 0.05 0.04 .25 0.01 0.06 .92 0.08 0.04 .06 0.12 0.08 .15 0.06 0.02 <.01 
EGF −0.02 0.02 .48 0.01 0.03 .77 0 0.02 .84 −0.01 0.03 .82 0 0.01 .83 
IL7 0 0.07 .94 0.21 0.09 .04 −0.05 0.04 .15 −0.01 0.06 .90 −0.01 0.03 .64 
sVCAM 0.08 0.04 .06 0.05 0.04 .25 −0.01 0.03 .69 0.02 0.04 .68 0.03 0.02 .15 
MIP-1α 0.01 0.01 .35 0 0.01 .85 −0.01 0.01 .49 0.01 0.01 .59 0 0 .83 
MIP-1β 0.07 0.04 .07 0.06 0.06 .36 0.03 0.04 .36 0.13 0.05 .02 0.06 0.02 <.01 
sCD40L 0 0.01 .70 0 0.01 .92 0 0.01 .89 0 0.01 .81 0 0.01 .94 
IFN-α2 0.03 0.02 .22 0.10 0.03 <.01 −0.01 0.02 .74 0.05 0.03 .09 0.02 0.01 .04 
IL-4 0.05 0.03 .13 0.08 0.04 .06 0 0.03 .88 0.04 0.03 .21 0.03 0.02 .05 
NT-proBNP 0.04 0.02 .05 0.03 0.03 .37 0 0.02 .88 −0.05 0.03 .14 0.01 0.01 .31 
UPCR 0.02 0.03 .60 0.04 0.05 .41 0.04 0.02 .08 0.04 0.04 .32 0.04 0.02 .01 
ACS† 0.01 0.08 .87 −0.08 0.08 .27 0.01 0.04 .84 −0.06 0.09 .53 0.01 0.03 .86 
VOC† 0.00 0.02 .86 0.02 0.01 .04 0.00 0.01 .84 −0.01 0.03 .65 0.00 0.01 .55 
ACS + VOC† 0.00 0.02 .89 0.02 0.01 .06 0.00 0.01 .89 −0.01 0.02 .56 0.00 0.01 .55 

Slope estimate (Est), standard error (SE), and P values were calculated using LMMs, adjusting age at baseline, sex, time point, and group (only for All). PFDR > .05 for all tests.

VOC, acute (vaso-occlusive) pain crisis; VWF, von Willebrand factor.

*

With the exception of Hb, ARC, and CRP, the cube root of laboratory values were used in LMMs.

†

The effect of event counts on TRV, where the estimate is the slope of the regression curve.

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