Patients characteristics at diagnosis
| Variables . | All, N (%) . | Extranodal, n (%) . | Nodal, n (%) . | P* . |
|---|---|---|---|---|
| Number, n | 341 | 224 (66) | 117 (34) | |
| Median age (range), y | 60 (18-88) | 61 (21-88) | 58 (18-88) | .27 |
| Male | 169 (50) | 111 (50) | 58 (50) | .95 |
| ECOG | ||||
| 0-1 | 332 (97) | 216 (96) | 116 (99) | .17 |
| ≥2 | 9 (3) | 8 (4) | 1 (1) | |
| Bulky (>7 cm) | 32 (10) | 21 (11) | 11 (9) | |
| Missing | 36 (11) | 35 (16) | 1 (1) | .70 |
| B symptoms | 10 (3) | 5 (2) | 5 (4) | .32 |
| Serum LDH | ||||
| Above normal | 69 (22) | 48 (23) | 21 (20) | .67 |
| Missing | 25 (7) | 13 (6) | 12 (10) | |
| SM-IPI score | ||||
| Missing | 25 (7) | 12 (5) | 13 (11) | † |
| 0 | 127 (37) | 80 (36) | 47 (40) | |
| 1 | 146 (43) | 100 (45) | 46 (39) | |
| 2 | 39 (11) | 29 (13) | 10 (9) | |
| 3 | 4 (1) | 3 (1) | 1(1) | |
| Treatment | ||||
| R-CHOP × 3-4 | 47 (14) | 28 (13) | 19 (16) | <.001 |
| R-CHOP × 3-4 + RT | 172 (50) | 98 (44) | 74 (63) | |
| R-CHOP × 6 | 60 (18) | 41 (18) | 19 (16) | |
| R-CHOP × 6 + RT | 62 (28) | 57 (25) | 5 (4) | |
| Combined modality | ||||
| Yes | 234 (69) | 155 (69) | 79 (68) | .75 |
| No | 107 (31) | 69 (31) | 38 (32) | |
| RT dose,cGy | ||||
| Median | 3060 | 3060 | 3060 | .28 |
| Range | 3000-4500‡ | 3000-4500 | 3000-4500 | |
| Complete excision before treatment | 84 (25) | 52 (23) | 32 (27) | .4 |
| CNS prophylaxis | 48 (14) | 47 (21) | 1 (1) | <.001 |
| Cell of origin | ||||
| Germinal center | 160 (47) | 98 (44) | 62 (53) | .06 |
| Non–germinal center | 89 (26) | 65 (29) | 24 (21) | |
| Missing | 92 (27) | 61 (27) | 31 (26) |
| Variables . | All, N (%) . | Extranodal, n (%) . | Nodal, n (%) . | P* . |
|---|---|---|---|---|
| Number, n | 341 | 224 (66) | 117 (34) | |
| Median age (range), y | 60 (18-88) | 61 (21-88) | 58 (18-88) | .27 |
| Male | 169 (50) | 111 (50) | 58 (50) | .95 |
| ECOG | ||||
| 0-1 | 332 (97) | 216 (96) | 116 (99) | .17 |
| ≥2 | 9 (3) | 8 (4) | 1 (1) | |
| Bulky (>7 cm) | 32 (10) | 21 (11) | 11 (9) | |
| Missing | 36 (11) | 35 (16) | 1 (1) | .70 |
| B symptoms | 10 (3) | 5 (2) | 5 (4) | .32 |
| Serum LDH | ||||
| Above normal | 69 (22) | 48 (23) | 21 (20) | .67 |
| Missing | 25 (7) | 13 (6) | 12 (10) | |
| SM-IPI score | ||||
| Missing | 25 (7) | 12 (5) | 13 (11) | † |
| 0 | 127 (37) | 80 (36) | 47 (40) | |
| 1 | 146 (43) | 100 (45) | 46 (39) | |
| 2 | 39 (11) | 29 (13) | 10 (9) | |
| 3 | 4 (1) | 3 (1) | 1(1) | |
| Treatment | ||||
| R-CHOP × 3-4 | 47 (14) | 28 (13) | 19 (16) | <.001 |
| R-CHOP × 3-4 + RT | 172 (50) | 98 (44) | 74 (63) | |
| R-CHOP × 6 | 60 (18) | 41 (18) | 19 (16) | |
| R-CHOP × 6 + RT | 62 (28) | 57 (25) | 5 (4) | |
| Combined modality | ||||
| Yes | 234 (69) | 155 (69) | 79 (68) | .75 |
| No | 107 (31) | 69 (31) | 38 (32) | |
| RT dose,cGy | ||||
| Median | 3060 | 3060 | 3060 | .28 |
| Range | 3000-4500‡ | 3000-4500 | 3000-4500 | |
| Complete excision before treatment | 84 (25) | 52 (23) | 32 (27) | .4 |
| CNS prophylaxis | 48 (14) | 47 (21) | 1 (1) | <.001 |
| Cell of origin | ||||
| Germinal center | 160 (47) | 98 (44) | 62 (53) | .06 |
| Non–germinal center | 89 (26) | 65 (29) | 24 (21) | |
| Missing | 92 (27) | 61 (27) | 31 (26) |
cGy, centigray; ECOG, Eastern Cooperative Oncology Group; LDH, lactate dehydrogenase.
P values calculated excluding missing values.
P value cannot be calculated because of sparse cells.
One patient cannot complete the planned RT and received a total dose of 2700 cGy. One patient with concomitant breast lymphoma and breast cancer received a dose of 6000 cGy.