Table 2.

Multivariate analysis for PFS and OS in the HO87 and CoMMpass data sets

TrialnPFSOS
Hazard ratio95% CIPHazard ratio95% CIP
HO87 (N = 168)        
 SKY92        
  SR 146 1.0  5.1 × 10−4 1.0  6.3 × 10−0 
  HR 22 2.6 1.6-4.3 3.1 1.9-5.1 
 R-ISS        
  I 30 1.0  2.0 × 10−2 1.0  2.6 × 10−3 
  II 126 1.9 1.1-3.2 2.1 1.2-3.8 
  III 12 2.6 1.2-5.8 4.0 1.8-9.3 
  Events = 118; 3 df 3 × 10−5 Events = 107; 3 df 1 × 10−0 
CoMMpass (N = 93)        
 SKY92        
  SR 69 1.0  1.7 × 10−3 1.0  2.8 × 10−0 
  HR 24 2.7 1.5-4.9 4.2 1.9-4.2 
 R-ISS        
  I 22 1.0  .031 *  3.8 × 10−0 
  II 59 2.5 1.2-5.5  
  III 12 2.2 0.76-6.5  
  Events = 53; 3 df 7 × 10−4 Events = 29; 3 df 2 × 10−0 
TrialnPFSOS
Hazard ratio95% CIPHazard ratio95% CIP
HO87 (N = 168)        
 SKY92        
  SR 146 1.0  5.1 × 10−4 1.0  6.3 × 10−0 
  HR 22 2.6 1.6-4.3 3.1 1.9-5.1 
 R-ISS        
  I 30 1.0  2.0 × 10−2 1.0  2.6 × 10−3 
  II 126 1.9 1.1-3.2 2.1 1.2-3.8 
  III 12 2.6 1.2-5.8 4.0 1.8-9.3 
  Events = 118; 3 df 3 × 10−5 Events = 107; 3 df 1 × 10−0 
CoMMpass (N = 93)        
 SKY92        
  SR 69 1.0  1.7 × 10−3 1.0  2.8 × 10−0 
  HR 24 2.7 1.5-4.9 4.2 1.9-4.2 
 R-ISS        
  I 22 1.0  .031 *  3.8 × 10−0 
  II 59 2.5 1.2-5.5  
  III 12 2.2 0.76-6.5  
  Events = 53; 3 df 7 × 10−4 Events = 29; 3 df 2 × 10−0 

HO87 was used as the discovery set, and CoMMpass was used as the validation set.

df, degrees of freedom.

*

Hazard ratios could not be determined because the R-ISS I group did not have any event.

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