Table 2. Impact of high-risk cytogenetic... | American Society of Hematology

Table 2.

Impact of high-risk cytogenetic aberrations on PFS

Definition of high-risk cytogenetic profile	Studies in patients with NDMM						Studies in patients with RRMM
	MAIA⁴		ALCYONE²¹		CASSIOPEIA⁶		POLLUX²²		CASTOR²³		CANDOR²⁴		ICARIA²⁵		IKEMA²⁶
	t(4;14), t(14;16), or del(17p) by FISH or karyotype analysis		t(4;14), t(14;16), or del(17p) by FISH or karyotype analysis		del(17p) with cutoff 50% or t(4;14) with cutoff 30% by FISH		t(4;14), t(14;16), or del(17p) by FISH or karyotype analysis		t(4;14), t(14;16), or del(17p) by FISH or karyotype analysis		del(17p), t(14;16) or t(4;14) by FISH		del(17p) with cutoff of 50%; t(14;16) with cutoff 30%; or t(4;14) with cutoff 30% by FISH		del(17p) with cutoff of 50%; t(14;16) with cutoff 30%; or t(4;14) with cutoff 30% by FISH
Cytogenetic risk category	Standard	High	Standard	High	Standard	High	Standard	High	Standard	High	Standard	High	Standard	High	Standard	High
No. of patients	550	92	518	98	914	168	369	70	258	95	156	74	181	60	192	73
Median follow-up, mo	36.4	36.4	27.8	27.8	18.8	18.8	44.3	44.3	50.2	50.2	16.9	16.9	11.6	11.6	20.7	20.7
PFS
HR	0.50	0.57	0.34	0.78	0.41	0.67	0.43	0.34	0.25	0.41	0.55	0.58	0.62	0.66	0.44	0.72
95% CI	0.38-0.65	0.32-1.04	0.26-0.45	0.49-1.26	0.26-0.62	0.35-1.30	0.32-0.57	0.16-0.72	0.18-0.35	0.21-0.83	0.31-0.97	0.30-1.12	0.42-0.93	0.33-1.28	0.27-0.73	0.36-1.45

Definition of high-risk cytogenetic profile	Studies in patients with NDMM						Studies in patients with RRMM
	MAIA⁴		ALCYONE²¹		CASSIOPEIA⁶		POLLUX²²		CASTOR²³		CANDOR²⁴		ICARIA²⁵		IKEMA²⁶
	t(4;14), t(14;16), or del(17p) by FISH or karyotype analysis		t(4;14), t(14;16), or del(17p) by FISH or karyotype analysis		del(17p) with cutoff 50% or t(4;14) with cutoff 30% by FISH		t(4;14), t(14;16), or del(17p) by FISH or karyotype analysis		t(4;14), t(14;16), or del(17p) by FISH or karyotype analysis		del(17p), t(14;16) or t(4;14) by FISH		del(17p) with cutoff of 50%; t(14;16) with cutoff 30%; or t(4;14) with cutoff 30% by FISH		del(17p) with cutoff of 50%; t(14;16) with cutoff 30%; or t(4;14) with cutoff 30% by FISH
Cytogenetic risk category	Standard	High	Standard	High	Standard	High	Standard	High	Standard	High	Standard	High	Standard	High	Standard	High
No. of patients	550	92	518	98	914	168	369	70	258	95	156	74	181	60	192	73
Median follow-up, mo	36.4	36.4	27.8	27.8	18.8	18.8	44.3	44.3	50.2	50.2	16.9	16.9	11.6	11.6	20.7	20.7
PFS
HR	0.50	0.57	0.34	0.78	0.41	0.67	0.43	0.34	0.25	0.41	0.55	0.58	0.62	0.66	0.44	0.72
95% CI	0.38-0.65	0.32-1.04	0.26-0.45	0.49-1.26	0.26-0.62	0.35-1.30	0.32-0.57	0.16-0.72	0.18-0.35	0.21-0.83	0.31-0.97	0.30-1.12	0.42-0.93	0.33-1.28	0.27-0.73	0.36-1.45

FISH, fluorescence in situ hybridization; RRMM, relapsed/refractory multiple myeloma.