Table 1. Main features of microcytic... | American Society of Hematology

Table 1.

Main features of microcytic anemias

	Acquired conditions		Inherited conditions
	IDA	ACD	BT trait	IRIDA	AHMIO1	AHMIO2	EPP1/2	SIDBA1	SIDBA2	SIDBA3	ASAT	Hypotransferrinemia
Genetic features
Causative gene(s)	—	—	HBB	TMPRSS6	SLC11A2	STEAP3	FECH/CLPX	ALAS2	SLC25A38	GLRX5	ABCB7	TF
Inheritance	—	—	AR	AR	AR	AD	AR/AD	XLR	AR	AR	XLR	AR
Hematological and biochemical features
RBC	↓	↓	↑	↓↓	↓	↓	↓	↓	↓	↓	↓	↓
Hb	↓	↓	= or ↓	↓ or ↓↓	↓↓	↓↓	↓	↓	↓↓	↓↓↓ (age dependent)	↓	↓
MCV	↓	↓	↓	↓↓	↓↓↓	↓	↓↓	↓	↓	↓↓	↓	↓↓
RDW	=	= or ↑	= or ↑	=	=	↑	=	=	↑	=	=	=
Reticulocytes	↓	= or ↑	= or ↑	↓	↓	↓	↓	↓	↓	↓	↓	↓
Tsat	↓↓	=	=	↓↓ or ↓↓↓	↑↑	↑↑	↑	↑	↑	↑	↑	100%
Ferritin	= or ↓	=	=	= or ↓	↑	↑	=	=	=	=	=	=
FEP	= or ↑	=	=	↑↑	↑	=	↑↑↑	= or ↓	=	=	= or ↓	=
Iron administration
Oral response	Yes	Unpredictable	No	No	No	—	No	No	—	No	No	No
Intravenous response	Yes	Unpredictable	No	Yes (not long lasting)	No	—	No	No	—	No	No	No
Suggested therapy	Oral iron supplement	Etiologic therapy (EPO, IV iron)	—	—	EPO	—	β-carotene	Vitamin B₆	—	Iron chelation	Vitamin B₆	Plasma; apotransferrin

	Acquired conditions		Inherited conditions
	IDA	ACD	BT trait	IRIDA	AHMIO1	AHMIO2	EPP1/2	SIDBA1	SIDBA2	SIDBA3	ASAT	Hypotransferrinemia
Genetic features
Causative gene(s)	—	—	HBB	TMPRSS6	SLC11A2	STEAP3	FECH/CLPX	ALAS2	SLC25A38	GLRX5	ABCB7	TF
Inheritance	—	—	AR	AR	AR	AD	AR/AD	XLR	AR	AR	XLR	AR
Hematological and biochemical features
RBC	↓	↓	↑	↓↓	↓	↓	↓	↓	↓	↓	↓	↓
Hb	↓	↓	= or ↓	↓ or ↓↓	↓↓	↓↓	↓	↓	↓↓	↓↓↓ (age dependent)	↓	↓
MCV	↓	↓	↓	↓↓	↓↓↓	↓	↓↓	↓	↓	↓↓	↓	↓↓
RDW	=	= or ↑	= or ↑	=	=	↑	=	=	↑	=	=	=
Reticulocytes	↓	= or ↑	= or ↑	↓	↓	↓	↓	↓	↓	↓	↓	↓
Tsat	↓↓	=	=	↓↓ or ↓↓↓	↑↑	↑↑	↑	↑	↑	↑	↑	100%
Ferritin	= or ↓	=	=	= or ↓	↑	↑	=	=	=	=	=	=
FEP	= or ↑	=	=	↑↑	↑	=	↑↑↑	= or ↓	=	=	= or ↓	=
Iron administration
Oral response	Yes	Unpredictable	No	No	No	—	No	No	—	No	No	No
Intravenous response	Yes	Unpredictable	No	Yes (not long lasting)	No	—	No	No	—	No	No	No
Suggested therapy	Oral iron supplement	Etiologic therapy (EPO, IV iron)	—	—	EPO	—	β-carotene	Vitamin B₆	—	Iron chelation	Vitamin B₆	Plasma; apotransferrin

ACD, anemia of chronic disease; AD, autosomal dominant; AHMIO, anemia, hypochromic microcytic, with iron overload; AR, autosomal recessive; ASAT, sideroblastic anemia with ataxia; BT, β-thalassemia; EPO, erythropoietin; EPP, erythropoietic protoporphyria; FEP, free erythrocyte porphyrin; SIDBA, sideroblastic anemia; XLR, X-linked recessive.

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