Selected relevant references
| Conditions . | References . |
|---|---|
| Neurologic POEMS syndrome Distal acquired demyelinating symmetric neuropathy with monoclonal protein (DADS-M) Chronic ataxic neuropathy, ophthalmoplegia, IgM paraprotein, cold agglutinins, and disialosyl antibodies (CANOMAD) Sporadic late-onset nemaline myopathy (SLOMN) | 3-6,7,8 9 |
| Renal10 AL amyloidosis Monoclonal immunoglobulin deposition disease Proliferative glomerulonephritis with monoclonal immunoglobulin deposition (PGMID) Monoclonal fibrillary glomerulonephritis Monoclonal fibrillary glomerulonephritis Cryoglobulinemia Immunotactoid glomerulonephritis Acquired Fanconi syndrome and other light chain proximal tubulopathies Crystal-storing histiocytosis C3 glomerulonephritis Monoclonal gammopathy–associated thrombotic microangiopathy | 30,12,13,11,31,32,25,26,33,34,29,35 36 |
| Dermatologic Schnitzler syndrome Scleromyxedema Necrobiotica xanthogranuloma Hyperlipidemic and nonhyperlipidemic xanthomatosis TEMPI syndrome Acquired cutis laxa Neutrophilic dermatosis Clarkson disease (systemic capillary leak syndrome) Macroglobulinosis | 14-17,18-20,21,22,22,23,37,38,27,28 39 |
| Other Monoclonal gammopathy keratopathy Acquired C1 inhibitor deficiency Acquired von Willebrand disease Cold agglutinin disease | 40,41,42 43 |
| Conditions . | References . |
|---|---|
| Neurologic POEMS syndrome Distal acquired demyelinating symmetric neuropathy with monoclonal protein (DADS-M) Chronic ataxic neuropathy, ophthalmoplegia, IgM paraprotein, cold agglutinins, and disialosyl antibodies (CANOMAD) Sporadic late-onset nemaline myopathy (SLOMN) | 3-6,7,8 9 |
| Renal10 AL amyloidosis Monoclonal immunoglobulin deposition disease Proliferative glomerulonephritis with monoclonal immunoglobulin deposition (PGMID) Monoclonal fibrillary glomerulonephritis Monoclonal fibrillary glomerulonephritis Cryoglobulinemia Immunotactoid glomerulonephritis Acquired Fanconi syndrome and other light chain proximal tubulopathies Crystal-storing histiocytosis C3 glomerulonephritis Monoclonal gammopathy–associated thrombotic microangiopathy | 30,12,13,11,31,32,25,26,33,34,29,35 36 |
| Dermatologic Schnitzler syndrome Scleromyxedema Necrobiotica xanthogranuloma Hyperlipidemic and nonhyperlipidemic xanthomatosis TEMPI syndrome Acquired cutis laxa Neutrophilic dermatosis Clarkson disease (systemic capillary leak syndrome) Macroglobulinosis | 14-17,18-20,21,22,22,23,37,38,27,28 39 |
| Other Monoclonal gammopathy keratopathy Acquired C1 inhibitor deficiency Acquired von Willebrand disease Cold agglutinin disease | 40,41,42 43 |
A single category was chosen for systemic diseases. See Figure 2, which demonstrates multiorgan involvement.
AL, amyloid light chain; POEMS, polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes; TEMPI, telangiectasias, elevated erythropoietin and erythropoiesis, monoclonal gammopathy, perinephric fluid, intrapulmonary shunting.