Available allogeneic CAR-expressed immune effector cells in MM
| Product . | Trial . | ClinicalTrials.gov identifier . | Phase . | Type . | Target . | Vector . | Gene editing event . | Inclusion . | n (estimated) . | Status . |
|---|---|---|---|---|---|---|---|---|---|---|
| UCARTCS1 | MELANI-01 | NCT04142619 | 1 | CAR T | CS1 | Lentivirus | TALEN | RRMM | 18 | Recruiting |
| ALLO-715 | UNIVERSAL | NCT04093596 | 1 | CAR T | BCMA | Lentivirus | TALEN | RRMM | 90 | Recruiting |
| PBCAR269A | PBCAR269A-01 | NCT04171843 | 1/2a | CAR T | BCMA | Adenovirus | ARCUS endonuclease | RRMM | 48 | Recruiting |
| CTX120 | Unnamed | NCT04244656 | 1 | CAR T | BCMA | CRISPR/Cas9 | CRISPR/Cas9 | RRMM | 80 | Recruiting |
| BCMA-UCART | Unnamed | NCT03752541 | 1 | CAR T | BCMA | Unknown | Unknown | RRMM | 20 | Recruiting |
| Product . | Trial . | ClinicalTrials.gov identifier . | Phase . | Type . | Target . | Vector . | Gene editing event . | Inclusion . | n (estimated) . | Status . |
|---|---|---|---|---|---|---|---|---|---|---|
| UCARTCS1 | MELANI-01 | NCT04142619 | 1 | CAR T | CS1 | Lentivirus | TALEN | RRMM | 18 | Recruiting |
| ALLO-715 | UNIVERSAL | NCT04093596 | 1 | CAR T | BCMA | Lentivirus | TALEN | RRMM | 90 | Recruiting |
| PBCAR269A | PBCAR269A-01 | NCT04171843 | 1/2a | CAR T | BCMA | Adenovirus | ARCUS endonuclease | RRMM | 48 | Recruiting |
| CTX120 | Unnamed | NCT04244656 | 1 | CAR T | BCMA | CRISPR/Cas9 | CRISPR/Cas9 | RRMM | 80 | Recruiting |
| BCMA-UCART | Unnamed | NCT03752541 | 1 | CAR T | BCMA | Unknown | Unknown | RRMM | 20 | Recruiting |
ClinicalTrials.gov access date was 30 May 2020.
CS1, CD2 subset 1; TALEN, transcription activator-like effector nucleases.