Patient characteristics stratified by allele burden
| . | Total . | JAK2V617F allele burden . | P* . | ||||
|---|---|---|---|---|---|---|---|
| Negative . | >0%-25% . | 25%-50% . | 50%-75% . | >75% . | |||
| . | N = 536 . | n = 80 . | n = 132 . | n = 124 . | n = 79 . | n = 121 . | |
| Age, median (range), y | 67 (23-87) | 66 (33-84) | 66 (28-85) | 67.5 (23-87) | 67 (39-84) | 68 (27-85) | .0365 |
| Sex, n (%) | .0322 | ||||||
| Female | 302 (56.3) | 43 (53.8) | 84 (63.6) | 72 (58.1) | 41 (51.9) | 62 (51.2) | |
| Male | 234 (43.7) | 37 (46.3) | 48 (36.4) | 52 (41.9) | 38 (48.1) | 59 (48.8) | |
| Race, n (%) | .7959 | ||||||
| Asian | 8 (1.5) | 1 (1.3) | 2 (1.5) | 4 (3.2) | 1 (1.3) | 0 (0.0) | |
| Black or African American | 3 (0.6) | 2 (2.5) | 0 (0.0) | 1 (0.8) | 0 (0.0) | 0 (0.0) | |
| Native Hawaiian or other Pacific Islander | 3 (0.6) | 1 (1.3) | 1 (0.8) | 0 (0.0) | 1 (1.3) | 0 (0.0) | |
| White | 476 (88.8) | 66 (82.5) | 122 (92.4) | 107 (86.3) | 72 (91.1) | 109 (90.1) | |
| Other | 1 (0.2) | 1 (1.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Unknown | 45 (8.4) | 9 (11.3) | 7 (5.3) | 12 (9.7) | 5 (6.3) | 12 (9.9) | |
| ECOG performance status, n (%) | .7984 | ||||||
| 0 | 127 (23.7) | 21 (26.3) | 25 (18.9) | 32 (25.8) | 25 (31.6) | 24 (19.8) | |
| 1 | 328 (61.2) | 45 (56.3) | 89 (67.4) | 72 (58.1) | 41 (51.9) | 81 (66.9) | |
| 2 | 68 (12.7) | 13 (16.3) | 16 (12.1) | 17 (13.7) | 9 (11.4) | 13 (10.7) | |
| 3 | 8 (1.5) | 1 (1.3) | 0 (0.0) | 2 (1.6) | 3 (3.8) | 2 (1.7) | |
| Missing | 5 (0.9) | 0 (0.0) | 2 (1.5) | 1 (0.8) | 1 (1.3) | 1 (0.8) | |
| . | Total . | JAK2V617F allele burden . | P* . | ||||
|---|---|---|---|---|---|---|---|
| Negative . | >0%-25% . | 25%-50% . | 50%-75% . | >75% . | |||
| . | N = 536 . | n = 80 . | n = 132 . | n = 124 . | n = 79 . | n = 121 . | |
| Age, median (range), y | 67 (23-87) | 66 (33-84) | 66 (28-85) | 67.5 (23-87) | 67 (39-84) | 68 (27-85) | .0365 |
| Sex, n (%) | .0322 | ||||||
| Female | 302 (56.3) | 43 (53.8) | 84 (63.6) | 72 (58.1) | 41 (51.9) | 62 (51.2) | |
| Male | 234 (43.7) | 37 (46.3) | 48 (36.4) | 52 (41.9) | 38 (48.1) | 59 (48.8) | |
| Race, n (%) | .7959 | ||||||
| Asian | 8 (1.5) | 1 (1.3) | 2 (1.5) | 4 (3.2) | 1 (1.3) | 0 (0.0) | |
| Black or African American | 3 (0.6) | 2 (2.5) | 0 (0.0) | 1 (0.8) | 0 (0.0) | 0 (0.0) | |
| Native Hawaiian or other Pacific Islander | 3 (0.6) | 1 (1.3) | 1 (0.8) | 0 (0.0) | 1 (1.3) | 0 (0.0) | |
| White | 476 (88.8) | 66 (82.5) | 122 (92.4) | 107 (86.3) | 72 (91.1) | 109 (90.1) | |
| Other | 1 (0.2) | 1 (1.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Unknown | 45 (8.4) | 9 (11.3) | 7 (5.3) | 12 (9.7) | 5 (6.3) | 12 (9.9) | |
| ECOG performance status, n (%) | .7984 | ||||||
| 0 | 127 (23.7) | 21 (26.3) | 25 (18.9) | 32 (25.8) | 25 (31.6) | 24 (19.8) | |
| 1 | 328 (61.2) | 45 (56.3) | 89 (67.4) | 72 (58.1) | 41 (51.9) | 81 (66.9) | |
| 2 | 68 (12.7) | 13 (16.3) | 16 (12.1) | 17 (13.7) | 9 (11.4) | 13 (10.7) | |
| 3 | 8 (1.5) | 1 (1.3) | 0 (0.0) | 2 (1.6) | 3 (3.8) | 2 (1.7) | |
| Missing | 5 (0.9) | 0 (0.0) | 2 (1.5) | 1 (0.8) | 1 (1.3) | 1 (0.8) | |
ECOG, Eastern Cooperative Oncology Group.
P values to test the trend of continuous and ordinal variables were calculated with use of Jonckheere-Terpstra test and the trend of categorical variables were calculated using the Cochran-Armitage trend test.